Gene: GREB1

9687
-
growth regulating estrogen receptor binding 1
protein-coding
2p25.1
Ensembl:ENSG00000196208 MIM:611736 Vega:OTTHUMG00000141276 UniprotKB:Q4ZG55
NG_029429.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.402e-2 (AD)  7.580e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7562399chr2:11627156 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12476319chr2:11608280 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20954893chr2:11761803GREB13.770e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASTN10.831
PDK20.825
CLASP10.824
SYNE10.819
CLEC16A0.814
C20orf1940.812
PTPRF0.811
TRAK10.805
ZBTB430.805
ITSN10.803

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.511
SLAMF6-0.486
GZMA-0.476
OR4F5-0.474
C16orf54-0.462
C2orf83-0.458
TBX21-0.457
CD48-0.455
CD2-0.452
CD3G-0.452

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5171131,1-bis(4-hydroxyphenyl)cyclohexane"1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]"24856822
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of GREB1 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GREB1 mRNA"25510870
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of GREB1 mRNA"23384675
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"ESR1 protein inhibits the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of GREB1 mRNA]"23384675
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GREB1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GREB1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GREB1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GREB1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GREB1 mRNA"25510870
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene promotes the reaction [ESR1 protein binds to GREB1 enhancer]"20846786
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene promotes the reaction [NCOA3 protein binds to GREB1 enhancer]"20846786
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in increased expression of GREB1 mRNA"23583297
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of GREB1 mRNA"24349450
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GREB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GREB1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GREB1 mRNA26690555
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]22558281
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA]22558281
C016601afimoxifeneafimoxifene inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]22558281
C016601afimoxifeneafimoxifene inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA]22558281
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of GREB1 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GREB1 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GREB1 mRNA28522335
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of GREB1 mRNA16496412
D001151ArsenicArsenic affects the methylation of GREB1 gene25304211
C006632arsenic trioxideafimoxifene inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]22558281
C006632arsenic trioxideafimoxifene inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA]22558281
C006632arsenic trioxide[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA22558281
C006632arsenic trioxidearsenic trioxide results in increased expression of GREB1 mRNA22558281
C006632arsenic trioxidefulvestrant inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]22558281
C006632arsenic trioxidefulvestrant inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA]22558281
C006632arsenic trioxideS-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]22558281
C006632arsenic trioxideS-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA]22558281
C447119bazedoxifenebazedoxifene results in decreased expression of GREB1 mRNA19914376
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of GREB1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GREB1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GREB1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GREB1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GREB1 mRNA26238291
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GREB1 mRNA27858113
D004958Estradiol"1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]"24856822
D004958EstradiolARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]]24299737
D004958Estradiolbisphenol A promotes the reaction [Estradiol results in increased expression of GREB1 mRNA]24856822
D004958Estradiolbisphenol B promotes the reaction [Estradiol results in increased expression of GREB1 mRNA]24856822
D004958EstradiolESR1 protein inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]23384675
D004958EstradiolEstradiol affects the expression of GREB1 mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of GREB1 mRNA20404318
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to GREB1 promoter]24299737
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GREB1 mRNA19619570
D004958EstradiolEstradiol promotes the reaction [AHR protein binds to GREB1 promoter]24299737
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer]20068169|2084678
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to GREB1 promoter]23019147|2429973
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of GREB1 mRNA]20404318
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]20846786
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to GREB1 promoter]25721606
D004958EstradiolEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]24299737
D004958EstradiolEstradiol results in increased expression of GREB1 mRNA15849065|1598612
D004958Estradiol(+)-JQ1 compound affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to GREB1 promoter]]25721606
D004958Estradiol(+)-JQ1 compound inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]25721606
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of GREB1 mRNA17404688
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]21185374
D004958Estradiolsodium arsenite inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]17283378
D004958EstradiolTBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer]]20068169
D004958EstradiolTBX21 protein inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]20068169
D004958EstradiolTetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]24299737
D004958EstradiolEstradiol results in increased expression of GREB1 mRNA19484750|2004911
C053541bicalutamidebicalutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]16496412
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of GREB1 mRNA28591870
C006780bisphenol Abisphenol A analog results in increased expression of GREB1 mRNA23384675
C006780bisphenol Abisphenol A promotes the reaction [ESR1 protein binds to GREB1 promoter]23019147
C006780bisphenol Abisphenol A promotes the reaction [Estradiol results in increased expression of GREB1 mRNA]24856822
C006780bisphenol Abisphenol A results in increased expression of GREB1 mRNA16474171|2249477
C006780bisphenol AESR1 protein affects the reaction [bisphenol A results in increased expression of GREB1 mRNA]23384675
C006780bisphenol AESR1 protein inhibits the reaction [bisphenol A analog results in increased expression of GREB1 mRNA]23384675
C006780bisphenol Abisphenol A results in decreased expression of GREB1 mRNA25181051
C492482bisphenol Bbisphenol B promotes the reaction [Estradiol results in increased expression of GREB1 mRNA]24856822
C492482bisphenol Bbisphenol B results in increased expression of GREB1 mRNA28591870
C000611646bisphenol Fbisphenol F results in increased expression of GREB1 mRNA28591870
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GREB1 mRNA27858113
D019327Copper SulfateCopper Sulfate results in decreased expression of GREB1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GREB1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with ESR1 protein] results in increased expression of GREB1 mRNA18310284
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of GREB1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of GREB1 mRNA19167446
D003375CoumestrolESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of GREB1 mRNA]18310284
D016572CyclosporineCyclosporine results in decreased expression of GREB1 mRNA25562108
D017373Cyproterone AcetateCyproterone Acetate inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]16496412
C004742daidzeindaidzein results in increased expression of GREB1 mRNA23384675
C004742daidzeinESR1 protein inhibits the reaction [daidzein results in increased expression of GREB1 mRNA]23384675
D003622DapsoneDapsone analog inhibits the reaction [Metribolone results in increased expression of GREB1 mRNA]21440447
D003671DEET[fipronil co-treated with DEET] results in decreased expression of GREB1 mRNA27091632
D003907DexamethasoneDexamethasone results in increased expression of GREB1 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GREB1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of GREB1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of GREB1 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of GREB1 mRNA21527772
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GREB1 mRNA19371625
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GREB1 mRNA25242112
D002117CalcitriolCalcitriol results in increased expression of GREB1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of GREB1 mRNA21592394
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of GREB1 mRNA"23811387
D004726EndosulfanEndosulfan results in increased expression of GREB1 mRNA23384675
D004726EndosulfanESR1 protein inhibits the reaction [Endosulfan results in increased expression of GREB1 mRNA]23384675
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of GREB1 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of GREB1 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GREB1 mRNA18936297
D015025ZearalenoneZearalenone results in increased expression of GREB1 mRNA19371625|2249477
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of GREB1 mRNA27091632
C082360fipronilfipronil results in decreased expression of GREB1 mRNA27091632
D005485FlutamideFlutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]16496412
C070081fulvestrantfulvestrant inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]22558281
C070081fulvestrantfulvestrant inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA]22558281
C070081fulvestrantfulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA]20846786
C070081fulvestrantfulvestrant inhibits the reaction [resveratrol results in increased expression of GREB1 mRNA]20846786
C070081fulvestrantGREB1 mutant form results in decreased susceptibility to fulvestrant24169358
D019833GenisteinGenistein promotes the reaction [ESR1 protein binds to GREB1 promoter]23019147
D019833GenisteinGenistein results in increased expression of GREB1 mRNA16474171|1937162
C010974glyphosateglyphosate results in increased expression of GREB1 mRNA28711546
C554645GSK525762AGSK525762A results in decreased expression of GREB1 mRNA24874954
D017313FenretinideFenretinide results in increased expression of GREB1 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GREB1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to GREB1 promoter]]25721606
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]25721606
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GREB1 mRNA24874954|2675264
C006552kaempferolfulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA]20846786
C006552kaempferolkaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]20846786
C006552kaempferolkaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]20846786
C006552kaempferolkaempferol results in increased expression of GREB1 mRNA20846786
C008261lead acetatelead acetate results in increased expression of GREB1 mRNA20542052
C533894LG 100815LG 100815 results in decreased expression of GREB1 mRNA16951191
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to GREB1 promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GREB1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GREB1 mRNA26011545
D015741MetriboloneDapsone analog inhibits the reaction [Metribolone results in increased expression of GREB1 mRNA]21440447
D015741MetriboloneMetribolone results in increased expression of GREB1 mRNA16496412|2144044
D009285NaphthoquinonesNaphthoquinones results in increased expression of GREB1 mRNA23811387
D009532NickelNickel results in decreased expression of GREB1 mRNA24768652|2558310
C021277nilutamidenilutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]16496412
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of GREB1 mRNA19074003
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of GREB1 mRNA"16951191
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GREB1 mRNA"25510870
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of GREB1 mRNA17097637
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of GREB1 mRNA16474171
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of GREB1 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of GREB1 mRNA17404688|2086464
D011374ProgesteroneProgesterone results in decreased expression of GREB1 mRNA22238285
C045950propiconazolepropiconazole results in increased expression of GREB1 mRNA21278054
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]21185374
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of GREB1 mRNA21185374
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of GREB1 mRNA19167446
C059514resveratrolfulvestrant inhibits the reaction [resveratrol results in increased expression of GREB1 mRNA]20846786
C059514resveratrolresveratrol promotes the reaction [ESR1 protein binds to GREB1 enhancer]20846786
C059514resveratrolresveratrol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]20846786
C059514resveratrolresveratrol results in increased expression of GREB1 mRNA20846786
C059514resveratrolresveratrol promotes the reaction [ESR1 protein binds to GREB1 gene]24771768
C059514resveratrolresveratrol promotes the reaction [NCOA2 protein binds to GREB1 gene]24771768
D012715Sesame OilSesame Oil results in increased expression of GREB1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GREB1 mRNA25895662
D012906SmokeSmoke results in decreased expression of GREB1 mRNA21095227
C017947sodium arsenitesodium arsenite inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]17283378
C017947sodium arsenitesodium arsenite results in decreased expression of GREB1 mRNA17283378
D013629TamoxifenTamoxifen results in increased expression of GREB1 mRNA25123088
D013739Testosteronebicalutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]16496412
D013739TestosteroneCyproterone Acetate inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]16496412
D013739TestosteroneFlutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]16496412
D013739Testosteronenilutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]16496412
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of GREB1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of GREB1 mRNA16496412|2159239
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of GREB1 mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in decreased expression of GREB1 mRNA19074003
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]]24299737
D013749TetrachlorodibenzodioxinESR1 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 gene]]19574409
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to GREB1 promoter]24299737
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GREB1 mRNA19619570
D013749TetrachlorodibenzodioxinEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]24299737
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]24299737
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to GREB1 gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]24299737
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GREB1 mRNA19574409|1961957
D013792ThalidomideThalidomide results in increased expression of GREB1 mRNA28892372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GREB1 mRNA20133372
C012589trichostatin Atrichostatin A results in decreased expression of GREB1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of GREB1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of GREB1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GREB1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of GREB1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of GREB1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GREB1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15834280Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population. (2005 May)Kamide KJ Hypertens