Gene: ST18

9705
NZF3|ZC2H2C3|ZC2HC10|ZNF387
ST18, C2H2C-type zinc finger
protein-coding
8q11.23
Ensembl:ENSG00000147488 MIM:617155 Vega:OTTHUMG00000164233 UniprotKB:O60284
NC_000008.11
PubMed|SNP Mapped
10   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.874e-1 (AD)  6.315e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7829966chr8:52169257 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs17290977chr8:52156360 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3891723chr8:52146926 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7837915chr8:52145941 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7010548chr8:52142923 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3815868chr8:52136477 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11990195chr8:52134121 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs9694119chr8:52128630 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7821217chr8:52127160 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2114226chr8:52124789 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH3TC20.949
FOLH10.939
ASPA0.937
FRMD4B0.935
LDB30.935
PIEZO20.932
ANLN0.928
C21orf910.922
TRIM590.922
SLC44A10.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.429
CALB2-0.414
CHRNA2-0.412
SHISA8-0.405
LTK-0.401
PRTN3-0.398
NEUROD1-0.397
PCDH8-0.392
PAX2-0.388
GPR153-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ST18 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ST18 mRNA24449571
C006780bisphenol Abisphenol A affects the methylation of ST18 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of ST18 mRNA25181051|2909715
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ST18 promoter22457795
C037123cadmium sulfatecadmium sulfate results in decreased expression of ST18 mRNA12064557
D003471CuprizoneCuprizone results in decreased expression of ST18 mRNA27523638
D003513CycloheximideCycloheximide results in increased expression of ST18 mRNA23236509
D003561CytarabineCytarabine results in increased expression of ST18 mRNA21198554
D005947GlucoseGlucose results in increased expression of ST18 mRNA23236509
D007213IndomethacinIndomethacin results in increased expression of ST18 mRNA28201806
C011890kojic acidkojic acid results in decreased expression of ST18 mRNA16595896
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ST18 mRNA26378955
D011441PropylthiouracilPropylthiouracil results in decreased expression of ST18 mRNA24780913
D012834SilverSilver results in decreased expression of ST18 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of ST18 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of ST18 protein21925251
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ST18 mRNA26378955
C501413tesaglitazartesaglitazar results in increased expression of ST18 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST18 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ST18 promoter]19654925
D014635Valproic AcidValproic Acid results in decreased expression of ST18 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ST18 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18676404  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0008285negative regulation of cell proliferation-IDA15489893  
GO:0033209tumor necrosis factor-mediated signaling pathway-IMP18676404  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP18676404  
GO:0070102interleukin-6-mediated signaling pathway-IMP18676404  
GO:0070498interleukin-1-mediated signaling pathway-IMP18676404  
GO:2001269positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-IMP18676404  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA15489893  
GO:0032993protein-DNA complex-IDA18676404  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23981442Stress-response pathways are altered in the hippocampus of chronic alcoholics. (2013 Nov)McClintick JNAlcohol