Gene: NOS1AP

9722
6330408P19Rik|CAPON
nitric oxide synthase 1 adaptor protein
protein-coding
1q23.3
Ensembl:ENSG00000198929 MIM:605551 Vega:OTTHUMG00000024049 UniprotKB:O75052
NG_015979.1
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.346e-1 (AD)  2.867e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6681981chr1:162361831 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4656355chr1:162154007 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1932933chr1:162148256 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11231349chr1:162050656NOS1AP5.300e-9Smoking27651444
cg11231349chr1:162050656NOS1AP2.920e-8Tobacco smoking28225026
cg11231349chr1:162050656NOS1AP2.450e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MICAL20.948
SV2B0.944
SH3GL20.94
DIRAS20.939
IPCEF10.937
SRRM40.937
NPTX10.937
SATB20.935
NELL20.932
TBR10.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.538
YES1-0.537
HEY2-0.535
TFPI2-0.532
LRAT-0.529
MDFI-0.525
RNF135-0.525
MBNL3-0.509
ARHGEF5-0.509
WWTR1-0.507

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of NOS1AP mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NOS1AP gene27153756
D000638AmiodaroneAmiodarone results in increased expression of NOS1AP mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NOS1AP mRNA16483693
D001151ArsenicArsenic affects the methylation of NOS1AP gene25304211
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of NOS1AP mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NOS1AP mRNA26238291
C006780bisphenol Abisphenol A results in decreased methylation of NOS1AP promoter27312807
C006780bisphenol Abisphenol A affects the expression of NOS1AP mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of NOS1AP mRNA24066056
C006780bisphenol Abisphenol A results in increased methylation of NOS1AP gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NOS1AP mRNA25993096
D019327Copper SulfateCopper Sulfate results in increased expression of NOS1AP mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of NOS1AP mRNA26577399
D003671DEETDEET results in decreased expression of NOS1AP mRNA27091632
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of NOS1AP mRNA28962523
C000944dicrotophosdicrotophos results in increased expression of NOS1AP mRNA28302478
D019422Dietary SucroseDietary Sucrose results in increased expression of NOS1AP mRNA26033743
C039281furanfuran results in decreased expression of NOS1AP mRNA25539665
D019833GenisteinGenistein results in increased methylation of NOS1AP gene28505145
D005839GentamicinsGentamicins results in decreased expression of NOS1AP mRNA22061828
D005897GlafenineGlafenine results in increased expression of NOS1AP mRNA24136188
D007657Ketone BodiesKetone Bodies results in increased expression of NOS1AP mRNA16807920
C045463leflunomideleflunomide results in increased expression of NOS1AP mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS1AP mRNA"24972896
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NOS1AP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NOS1AP mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NOS1AP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NOS1AP mRNA"25620056
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of NOS1AP mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NOS1AP mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NOS1AP mRNA]"21673326
D009966OrphenadrineOrphenadrine affects the expression of NOS1AP mRNA23665939
D010269ParaquatParaquat results in increased expression of NOS1AP mRNA20388547
D010936Plant ExtractsPlant Extracts results in decreased expression of NOS1AP mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of NOS1AP mRNA16293270
D011441PropylthiouracilPropylthiouracil results in decreased expression of NOS1AP mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in increased expression of NOS1AP mRNA23221170
D012906SmokeSmoke results in decreased expression of NOS1AP mRNA21095227
D012906SmokeSmoke results in increased expression of NOS1AP mRNA19133281
D014212TretinoinTretinoin results in decreased expression of NOS1AP mRNA20488242
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NOS1AP mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased methylation of NOS1AP gene29154799
C025643vinclozolinvinclozolin affects the expression of NOS1AP mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0050998nitric-oxide synthase binding-ISS9459447  
GO ID GO Term Qualifier Evidence PubMed
GO:0003062regulation of heart rate by chemical signal-IMP19247217  
GO:0010628positive regulation of gene expression-ISS18337493  
GO:0010750positive regulation of nitric oxide mediated signal transduction-ISS18337493  
GO:0045428regulation of nitric oxide biosynthetic process-NAS20431962  
GO:0045429positive regulation of nitric oxide biosynthetic process-ISS18337493  
GO:0050999regulation of nitric-oxide synthase activity-NAS20431962  
GO:0051000positive regulation of nitric-oxide synthase activity-ISS18337493  
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization-IMP19247217  
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization-ISS18337493  
GO:0098901regulation of cardiac muscle cell action potential-ISS18337493  
GO:0098901regulation of cardiac muscle cell action potential-TAS24665357  
GO:1901381positive regulation of potassium ion transmembrane transport-ISS18337493  
GO:1901841regulation of high voltage-gated calcium channel activity-ISS18337493  24665357  
GO:1902261positive regulation of delayed rectifier potassium channel activity-ISS18337493  
GO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channel-ISS18337493  
GO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channel-TAS24665357  
GO:1903762positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization-ISS18337493  
GO:2000170positive regulation of peptidyl-cysteine S-nitrosylation-ISS24665357  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS24665357  
GO:0005739mitochondrion-ISS19800018  
GO:0005829cytosol-ISS24665357  
GO:0005901caveolacolocalizes_withISS19800018  
GO:0030018Z disc-ISS19800018  
GO:0030315T-tubulecolocalizes_withISS24665357  
GO:0031965nuclear membranecolocalizes_withISS24665357  
GO:0033017sarcoplasmic reticulum membrane-ISS19800018  
GO:0042383sarcolemmacolocalizes_withISS18337493  
GO:0048471perinuclear region of cytoplasm-ISS18337493  
GO:1902937inward rectifier potassium channel complexcolocalizes_withISS24665357  
GO:1990454L-type voltage-gated calcium channel complexcolocalizes_withISS24665357  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28416970DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. (2017)Sundar IKClin Epigenetics
19643915Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study. (2009 Nov 1)Eijgelsheim MHum Mol Genet
18785031Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study. (2009)Raitakari OTAnn Med
27080431Sex-dichotomous effects of NOS1AP promoter DNA methylation on intracranial aneurysm and brain arteriovenous malformation. (2016 May 16)Wang ZNeurosci Lett