Gene: MAGI2

9863
ACVRIP1|AIP-1|AIP1|ARIP1|MAGI-2|SSCAM
membrane associated guanylate kinase, WW and PDZ domain containing 2
protein-coding
7q21.11
Ensembl:ENSG00000187391 MIM:606382 Vega:OTTHUMG00000130697 UniprotKB:Q86UL8
NG_011487.1
PubMed|SNP Mapped
10   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.969e-1 (AD)  3.125e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1609276chr7:79299845 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs514463chr7:78875415 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs13308578chr7:78779243 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12705591chr7:78562053 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs13242509chr7:78560896 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs12705579chr7:78554905 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs13245734chr7:78554235 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6466241chr7:78475159 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17150722chr7:78429448 (GRCh38.p7)A>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs3823787chr7:78143815 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CKAP50.918
FOXO30.911
PBX10.903
LSAMP0.903
SMARCA20.902
LONP20.902
TMEM2450.901
DNAJC180.9
KIAA11090.899
ANK20.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.621
OR4F29-0.601
TFPI2-0.429
SLAMF6-0.41
TBX21-0.402
SIX1-0.398
KLRB1-0.397
C2orf83-0.388
C16orf54-0.381
PGF-0.378

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of MAGI2 mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MAGI2 mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of MAGI2 mRNA"23829299
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MAGI2 mRNA22230336
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of MAGI2 mRNA25607892
D020106AcrylamideAcrylamide results in decreased expression of MAGI2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MAGI2 mRNA21632981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAGI2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MAGI2 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of MAGI2 mRNA25607892
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MAGI2 mRNA24449571
D001151ArsenicArsenic affects the methylation of MAGI2 gene25304211
C015001arsenitearsenite results in increased methylation of MAGI2 promoter23974009
D001205Ascorbic AcidAscorbic Acid results in increased expression of MAGI2 mRNA15305145
C487081belinostatbelinostat results in increased expression of MAGI2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAGI2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MAGI2 gene25435355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAGI2 mRNA"20382639
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAGI2 promoter23359474
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of MAGI2 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of MAGI2 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of MAGI2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MAGI2 gene28505145
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of MAGI2 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of MAGI2 mRNA25607892
C018475butyraldehydebutyraldehyde results in decreased expression of MAGI2 mRNA26079696
D003035Cobalt[tungsten carbide binds to Cobalt] which results in decreased expression of MAGI2 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in increased expression of MAGI2 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in decreased expression of MAGI2 mRNA24386269
C014347decitabinedecitabine results in decreased methylation of MAGI2 gene27923600
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAGI2 promoter23359474
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA25607892
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAGI2 promoter23359474
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA25607892
C118739entinostatentinostat results in increased expression of MAGI2 mRNA26272509
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of MAGI2 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of MAGI2 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA25607892
C039281furanfuran results in decreased expression of MAGI2 mRNA25539665
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA25607892
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MAGI2 mRNA21641980
D008731MethoxychlorMethoxychlor results in increased methylation of MAGI2 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MAGI2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MAGI2 mRNA"20188158|2625132
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MAGI2 mRNA24810058
C028473N-acetyl-4-benzoquinoneimineMAGI2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D009532NickelNickel results in decreased expression of MAGI2 mRNA24768652|2558310
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of MAGI2 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of MAGI2 mRNA25607892
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of MAGI2 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA25607892
D011794QuercetinQuercetin results in decreased expression of MAGI2 mRNA21632981
D012643SeleniumSelenium results in decreased expression of MAGI2 mRNA19244175
C017947sodium arsenitesodium arsenite affects the methylation of MAGI2 gene28589171
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MAGI2 mRNA21641980
D013849ThimerosalThimerosal results in decreased expression of MAGI2 mRNA27188386
D014212TretinoinTretinoin results in increased expression of MAGI2 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of MAGI2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MAGI2 mRNA"26179874
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in decreased expression of MAGI2 mRNA20105288
C002802tungsten carbidetungsten carbide results in decreased expression of MAGI2 mRNA20105288
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAGI2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MAGI2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of MAGI2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MAGI2 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MAGI2 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of MAGI2 mRNA25423262
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA25607892
D019287Zinc SulfateZinc Sulfate results in increased expression of MAGI2 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9647693  10548487  11526121  16316992  
GO:0019902phosphatase binding-IPI10760291  
GO:0030159receptor signaling complex scaffold activity-IDA11526121  
GO:0031697beta-1 adrenergic receptor binding-IPI11526121  
GO:0046332SMAD binding-ISS-  
GO:0070699type II activin receptor binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002092positive regulation of receptor internalization-IDA11526121  
GO:0003402planar cell polarity pathway involved in axis elongation-NAS20534871  
GO:0008285negative regulation of cell proliferation-ISS-  
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0030336negative regulation of cell migration-ISS-  
GO:0032516positive regulation of phosphoprotein phosphatase activity-IDA10760291  
GO:0032926negative regulation of activin receptor signaling pathway-ISS-  
GO:0038180nerve growth factor signaling pathway-ISS-  
GO:0043113receptor clustering-ISS-  
GO:0051291protein heterooligomerization-ISS-  
GO:0051898negative regulation of protein kinase B signaling-IDA10760291  
GO:0060395SMAD protein signal transduction-ISS-  
GO:0071850mitotic cell cycle arrest-ISS-  
GO:0072015glomerular visceral epithelial cell development-ISS-  
GO:0097118neuroligin clustering involved in postsynaptic membrane assembly-IEA-  
GO:1990090cellular response to nerve growth factor stimulus-ISS-  
GO:2000809positive regulation of synaptic vesicle clustering-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10760291  
GO:0005737cytoplasm-IDA11526121  
GO:0005770late endosome-ISS-  
GO:0005886plasma membrane-IDA10760291  11526121  
GO:0005923bicellular tight junction-IDA10760291  
GO:0014069postsynaptic density-ISS-  
GO:0030425dendrite-ISS-  
GO:0032991protein-containing complex-ISS-  
GO:0036057slit diaphragm-ISS-  
GO:0045202synapse-ISS-  
GO:0048471perinuclear region of cytoplasm-ISS-  
KEGG ID KEGG Term
hsa04530Tight junction
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-373753Nephrin family interactionsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25517131Novel genes for airway wall thickness identified with combined genome-wide association and expression analyses. (2015 Mar 1)Dijkstra AEAm J Respir Crit Care Med