Gene: ARNT2

9915
WEDAS|bHLHe1
aryl hydrocarbon receptor nuclear translocator 2
protein-coding
15q25.1
Ensembl:ENSG00000172379 MIM:606036 Vega:OTTHUMG00000165478 UniprotKB:Q9HBZ2
NC_000015.10
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.494e-1 (AD)  4.756e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4238521chr15:80503787 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4778800chr15:80487417 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABR0.952
PIP4K2B0.951
DCAF110.946
TNPO20.944
ARF30.942
SEPT30.938
CALM10.936
SMARCA20.933
CBX70.931
SPTAN10.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.761
OR4F29-0.73
TFPI2-0.365
C9orf135-0.353
SGMS2-0.332
CD48-0.33
SNHG18-0.329
SH2D1A-0.325
BEST3-0.32
IGF2BP2-0.318

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C54112011-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol"11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Estradiol results in decreased expression of ARNT2 mRNA]"22127542
C54112011-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol"11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol results in increased expression of ARNT2 mRNA"22127542
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [bisphenol A results in decreased expression of ARNT2 mRNA]"21771643
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [butylbenzyl phthalate results in decreased expression of ARNT2 mRNA]"21771643
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [o,p'-DDT results in decreased expression of ARNT2 mRNA]"21771643
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of ARNT2 mRNA"25565004
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ARNT2 mRNA"23146750
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ARNT2 mRNA"27291303
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ARNT2 mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ARNT2 mRNA26690555
C016601afimoxifeneafimoxifene results in increased expression of ARNT2 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ARNT2 mRNA27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ARNT2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ARNT2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ARNT2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of ARNT2 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of ARNT2 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of ARNT2 mRNA22323515
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARNT2 mRNA26001963
D001564Benzo(a)pyreneARNT2 protein inhibits the reaction [Oxygen deficiency inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]]19539049
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ARNT2 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of ARNT2 mRNA16514628
D004958Estradiol"11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Estradiol results in decreased expression of ARNT2 mRNA]"22127542
D004958EstradiolEstradiol affects the expression of ARNT2 mRNA24777823
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in decreased expression of ARNT2 mRNA26945725
D004958EstradiolEstradiol results in decreased expression of ARNT2 mRNA22127542
C044887beta-methylcholinebeta-methylcholine affects the expression of ARNT2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ARNT2 mRNA21786754
C006780bisphenol A"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [bisphenol A results in decreased expression of ARNT2 mRNA]"21771643
C006780bisphenol Abisphenol A affects the expression of ARNT2 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of ARNT2 mRNA21771643
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ARNT2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ARNT2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ARNT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ARNT2 gene28505145
C027561butylbenzyl phthalate"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [butylbenzyl phthalate results in decreased expression of ARNT2 mRNA]"21771643
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of ARNT2 mRNA21771643
D002104CadmiumCadmium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ARNT2 mRNA]29107029
D002104CadmiumCadmium results in decreased expression of ARNT2 mRNA29107029
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ARNT2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ARNT2 mRNA12734012
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARNT2 gene20938992
D003300CopperCopper deficiency results in increased expression of ARNT2 mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of ARNT2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of ARNT2 mRNA20106945
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ARNT2 mRNA"18606552
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of ARNT2 mRNA23640034
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ARNT2 mRNA16556975
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ARNT2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ARNT2 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ARNT2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ARNT2 mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of ARNT2 mRNA26033743
D004147DioxinsDioxins affects the expression of ARNT2 mRNA20463971
C012301domoic aciddomoic acid results in increased expression of ARNT2 mRNA18936300
D004726EndosulfanEndosulfan results in increased expression of ARNT2 mRNA26615145
C118739entinostatentinostat results in decreased expression of ARNT2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of ARNT2 mRNA12859947
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of ARNT2 protein12859947
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ARNT2 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ARNT2 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ARNT2 mRNA28196854
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ARNT2 mRNA20170705|2686566
D005419FlavonoidsFlavonoids results in increased expression of ARNT2 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARNT2 gene20938992
C070081fulvestrantfulvestrant results in increased expression of ARNT2 mRNA16514628
C039281furanfuran results in increased expression of ARNT2 mRNA27387713
C039281furanfuran results in increased methylation of ARNT2 gene22079235
D019833GenisteinGenistein results in decreased expression of ARNT2 mRNA26865667
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ARNT2 mRNA16556975
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ARNT2 mRNA"18606552
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ARNT2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ARNT2 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of ARNT2 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ARNT2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ARNT2 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of ARNT2 mRNA24286936
D007545IsoproterenolIsoproterenol results in increased expression of ARNT2 mRNA24286936
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ARNT2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARNT2 mRNA26752646
C002385linsidominelinsidomine results in increased oxidation of ARNT2 protein28086193
D008344Maneb[Maneb co-treated with Paraquat] results in increased expression of ARNT2 mRNA23017109
D008627Mercuric ChlorideMercuric Chloride affects the expression of ARNT2 mRNA20353558
D008694MethamphetamineMethamphetamine results in increased expression of ARNT2 mRNA15644446
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARNT2 gene20938992
D009151Mustard GasMustard Gas results in increased expression of ARNT2 mRNA15674843
C029938nickel sulfatenickel sulfate results in increased expression of ARNT2 mRNA22714537
C016340o,p'-DDT"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [o,p'-DDT results in decreased expression of ARNT2 mRNA]"21771643
C016340o,p'-DDT"o,p'-DDT results in decreased expression of ARNT2 mRNA"21771643
D010100OxygenARNT2 protein inhibits the reaction [Oxygen deficiency inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]]19539049
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of ARNT2 mRNA26272509
D010269Paraquat[Maneb co-treated with Paraquat] results in increased expression of ARNT2 mRNA23017109
D010578PetroleumPetroleum affects the expression of ARNT2 mRNA25208076
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in decreased expression of ARNT2 mRNA26945725
D011374ProgesteroneProgesterone affects the expression of ARNT2 mRNA24777823
D011441PropylthiouracilPropylthiouracil results in increased expression of ARNT2 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of ARNT2 mRNA16514628
C080703SK&F 83959SK&F 83959 results in decreased expression of ARNT2 protein25852303
D018038Sodium SeleniteSodium Selenite results in decreased expression of ARNT2 mRNA18175754
D013749TetrachlorodibenzodioxinARNT2 protein alternative form results in increased susceptibility to Tetrachlorodibenzodioxin11072074
D013749TetrachlorodibenzodioxinCadmium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ARNT2 mRNA]29107029
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of ARNT2 protein12130674
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARNT2 mRNA29107029
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with ARNT2 protein co-treated with AHR protein] results in increased expression of CYP1A5 mRNA21134488
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with ARNT2 protein] results in increased expression of CYP1A5 mRNA21134488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT2 protein]21134488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT2 protein]21134488
D013749TetrachlorodibenzodioxinARNT2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]18096572
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARNT2 mRNA24058054
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ARNT2 mRNA20133372
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ARNT2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ARNT2 mRNA"23306105
C057693troglitazonetroglitazone results in increased expression of ARNT2 mRNA19140230
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ARNT2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ARNT2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of ARNT2 mRNA24935251
D014638VanadatesVanadates results in decreased expression of ARNT2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ARNT2 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT2 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of ARNT2 mRNA26272509
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of ARNT2 mRNA"25208076
C088658zoledronic acidzoledronic acid results in decreased expression of ARNT2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA24465693  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0005515protein binding-IPI24465693  
GO:0017162aryl hydrocarbon receptor binding-ISS-  
GO:0046982protein heterodimerization activity-IDA24465693  
GO:0046982protein heterodimerization activity-IPI12239177  
GO:0046982protein heterodimerization activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IDA12239177  
GO:0001701in utero embryonic development-ISS-  
GO:0006355regulation of transcription, DNA-templated-IDA11782478  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0007417central nervous system development-ISS-  
GO:0007420brain development-IMP24022475  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA24465693  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12239177  24465693  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-211981XenobioticsTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8937144Aryl hydrocarbon receptor signallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal