Gene: IQSEC1

9922
ARF-GEP100|ARFGEP100|BRAG2|GEP100
IQ motif and Sec7 domain 1
protein-coding
3p25.2-p25.1
Ensembl:ENSG00000144711 MIM:610166 Vega:OTTHUMG00000155398 UniprotKB:Q6DN90
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.413e-1 (AD)  2.523e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs357159chr3:13267240 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20957164chr3:12965323IQSEC1Gene body4.127e-4Alcohol use disorders26763658
cg25157472chr3:12996362IQSEC18.300e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATXN7L30.962
PACSIN10.96
RNF1570.959
CDK160.957
CAMTA20.957
SEPT30.953
TTC7B0.952
BRSK10.952
SCAMP50.951
FBXO410.951

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.647
OR4F29-0.6
TFPI2-0.481
C9orf135-0.453
C1orf87-0.434
WWTR1-0.43
IL18RAP-0.427
CLEC2B-0.422
CST7-0.419
PLEKHA4-0.419

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IQSEC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IQSEC1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of IQSEC1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IQSEC1 mRNA27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IQSEC1 mRNA20064835|2010694
C044887beta-methylcholinebeta-methylcholine affects the expression of IQSEC1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of IQSEC1 mRNA25181051
C031180chrysenechrysene results in decreased expression of IQSEC1 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of IQSEC1 mRNA26378417
D019327Copper SulfateCopper Sulfate results in decreased expression of IQSEC1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of IQSEC1 mRNA25562108
D003976DiazinonDiazinon results in increased methylation of IQSEC1 gene22964155
C000944dicrotophosdicrotophos results in increased expression of IQSEC1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of IQSEC1 mRNA25016146
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of IQSEC1 protein23301498
D005485FlutamideFlutamide results in increased expression of IQSEC1 mRNA24136188
C492448ICG 001ICG 001 results in increased expression of IQSEC1 mRNA26191083
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of IQSEC1 mRNA"26377693
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IQSEC1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IQSEC1 mRNA23086925
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of IQSEC1 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IQSEC1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IQSEC1 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IQSEC1 mRNA"25554681
C022838nickel chloridenickel chloride results in increased expression of IQSEC1 mRNA26378417
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IQSEC1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of IQSEC1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IQSEC1 mRNA19710929
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IQSEC1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of IQSEC1 mRNA23557971
D014635Valproic AcidValproic Acid affects the expression of IQSEC1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of IQSEC1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IQSEC1 gene25560391
D014810Vitamin EVitamin E results in increased expression of IQSEC1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005086ARF guanyl-nucleotide exchange factor activity-IEA-  
GO:0005515protein binding-IPI27265506  
GO:0008289lipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032012regulation of ARF protein signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0016020membrane-HDA19946888  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal