Gene: DCLRE1A

9937
PSO2|SNM1|SNM1A
DNA cross-link repair 1A
protein-coding
10q25.3
Ensembl:ENSG00000198924 MIM:609682 Vega:OTTHUMG00000019077 UniprotKB:Q6PJP8
NC_000010.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.906e-1 (AD)  3.422e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10567chr10:113834966 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB11FIP20.927
C6orf1200.92
KLHL70.919
DPP80.917
NCKAP10.916
TRAPPC110.916
FAM160B10.916
NAA300.915
GTF3C40.914
CAND10.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.498
OR4F29-0.454
MTRNR2L6-0.388
CSAG1-0.378
MTRNR2L10-0.373
KLRK1-0.352
MTRNR2L9-0.352
HEY2-0.349
PPBP-0.333
KLRB1-0.33

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of DCLRE1A mRNA"26377693
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DCLRE1A mRNA"19167446
D000082AcetaminophenAcetaminophen affects the expression of DCLRE1A mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of DCLRE1A mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DCLRE1A mRNA]17585979
C006780bisphenol Abisphenol A results in decreased expression of DCLRE1A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DCLRE1A gene28505145
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of DCLRE1A mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DCLRE1A mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of DCLRE1A mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DCLRE1A mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of DCLRE1A mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of DCLRE1A mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of DCLRE1A mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of DCLRE1A mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of DCLRE1A mRNA27989131
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DCLRE1A mRNA]27941970
D002945CisplatinCisplatin results in increased expression of DCLRE1A mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of DCLRE1A mRNA28302478
D004317DoxorubicinDoxorubicin results in decreased expression of DCLRE1A mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of DCLRE1A mRNA]27181935
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DCLRE1A mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCLRE1A mRNA17942748
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of DCLRE1A mRNA]27181935
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DCLRE1A mRNA20044591
C492448ICG 001ICG 001 results in increased expression of DCLRE1A mRNA26191083
C051890irinotecanirinotecan metabolite results in decreased expression of DCLRE1A mRNA15956246
C051890irinotecanirinotecan results in decreased expression of DCLRE1A mRNA15956246
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DCLRE1A mRNA23430699|2530787
C410337K 7174K 7174 results in decreased expression of DCLRE1A mRNA24086573
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of DCLRE1A mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of DCLRE1A mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of DCLRE1A mRNA19270015
D010862PilocarpinePilocarpine results in increased expression of DCLRE1A mRNA17971868
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DCLRE1A mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DCLRE1A mRNA22079256
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of DCLRE1A mRNA19167446
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DCLRE1A mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCLRE1A mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DCLRE1A mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DCLRE1A mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DCLRE1A mRNA21215274
D014520UrethaneUrethane results in decreased expression of DCLRE1A mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of DCLRE1A gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DCLRE1A gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA binding-IBA21873635  
GO:00353125'-3' exodeoxyribonuclease activity-IBA21873635  
GO:00353125'-3' exodeoxyribonuclease activity-IDA22692201  
GO ID GO Term Qualifier Evidence PubMed
GO:0006303double-strand break repair via nonhomologous end joining-IBA21873635  
GO:0007049cell cycle-IEA-  
GO:0031848protection from non-homologous end joining at telomere-IBA21873635  
GO:0036297interstrand cross-link repair-IBA21873635  
GO:0036297interstrand cross-link repair-TAS-  
GO:0051301cell division-IEA-  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-IBA21873635  
GO:0001650fibrillar center-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6783310Fanconi Anemia PathwayTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal