DegronMD

Uniprot ID: P52740

Source protein: Zinc finger protein 132

Source gene: ZNF132

Class: DEG_SPOP_SBC_1

Location: 553:557

E3 ligase: SPOP

DEGRON score: 0.5322

ASA_SCORE: 66.18

COIL: 0.7568

CONS_SCORE: 0.398

DSS_SCORE: 0.1613

HELIX: 0.1424

FCONS_SCORE: 0.6258

RIG_SCORE: 0.7594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I559N	TCGA-CJ-4640	KIRC	TCGA	AHSST	DEG_SPOP_SBC_1	0.2778
p.I559N	DO16202	KIRC	ICGC	AHSST	DEG_SPOP_SBC_1	0.2778
p.R563G	TCGA-E6-A1LX	UCEC	TCGA	AHSST	DEG_SPOP_SBC_1	0.1667
p.R563G	DO41020	UCEC	ICGC	AHSST	DEG_SPOP_SBC_1	0.1667
p.E544K	TCGA-FI-A2D5	UCEC	TCGA	AHSST	DEG_SPOP_SBC_1	0.0833
p.E544K	DO41331	UCEC	ICGC	AHSST	DEG_SPOP_SBC_1	0.0833
p.E544G	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	AHSST	DEG_SPOP_SBC_1	0.0833
p.E544G	KYSE-410	oesophagus	COSMIC	AHSST	DEG_SPOP_SBC_1	0.0833
p.W562R	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	AHSST	DEG_SPOP_SBC_1	0.1944
p.W562R	ACH-000395	Lung Cancer	CCLE	AHSST	DEG_SPOP_SBC_1	0.1944
p.W562R	NCI-H520	lung	COSMIC	AHSST	DEG_SPOP_SBC_1	0.1944
p.E547K	SIDM00539	Esophageal Carcinoma	GDSC	AHSST	DEG_SPOP_SBC_1	0.1667
p.E547K	ACH-002089	Lung Cancer	CCLE	AHSST	DEG_SPOP_SBC_1	0.1667
p.E547K	201T	lung	COSMIC	AHSST	DEG_SPOP_SBC_1	0.1667
p.H565N	ACH-000777	Esophageal Cancer	CCLE	AHSST	DEG_SPOP_SBC_1	0.1111
p.E547V	ACH-000961	Endometrial/Uterine Cancer	CCLE	AHSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	264:268	AHSST	SPOP	0.8186	More...
P52740	Zinc finger protein 132	DEG_SPOP_SBC_1	553:557	AHSST	SPOP	0.5322	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons