DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
AHTTS
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
2271:2275
E3 ligase:
SPOP
DEGRON score:
0.9813
ASA_SCORE:
94.04
COIL:
0.9122
CONS_SCORE:
0.2948
DSS_SCORE:
0.6066
HELIX:
0.0308
FCONS_SCORE:
0.7886
RIG_SCORE:
0.714
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AHTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2271:2275
AHTTS
SPOP
0.9813
More...
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
1783:1787
AHTTS
SPOP
0.8802
More...