DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1783:1787

E3 ligase: SPOP

DEGRON score: 0.8802

ASA_SCORE: 93.54

COIL: 0.8104

CONS_SCORE: 0.335

DSS_SCORE: 0.7096

HELIX: 0.0156

FCONS_SCORE: 1.0588

RIG_SCORE: 0.6834

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1788S	TCGA-22-5472	LUSC	TCGA	AHTTS	DEG_SPOP_SBC_1	0.3056
p.A1788S	DO27421	LUSC	ICGC	AHTTS	DEG_SPOP_SBC_1	0.3056
p.T1778N	TCGA-96-A4JK	LUSC	TCGA	AHTTS	DEG_SPOP_SBC_1	0.1944
p.T1778N	DO45442	LUSC	ICGC	AHTTS	DEG_SPOP_SBC_1	0.1944
p.S1790N	TCGA-BR-A4QI	STAD	TCGA	AHTTS	DEG_SPOP_SBC_1	0.6944
p.S1790N	DO38523	STAD	ICGC	AHTTS	DEG_SPOP_SBC_1	0.6944
p.P1781H	TCGA-EO-A3KX	UCEC	TCGA	AHTTS	DEG_SPOP_SBC_1	0.2778
p.P1781H	DO219774	UCEC	ICGC	AHTTS	DEG_SPOP_SBC_1	0.2778
p.G1777D	DO224685	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.1667
p.H1773P	DO222540	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.H1773P	DO222741	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.H1773P	DO222770	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.H1773P	DO222866	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.H1773P	DO222894	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.H1773P	DO229010	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.H1773P	DO229013	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.H1773P	DO229016	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.H1773P	DO229003	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.H1773P	DO229005	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.0556
p.R1779G	DO222741	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.2222
p.R1779G	DO222866	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.2222
p.R1779G	DO222884	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.2222
p.R1779G	DO222894	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.2222
p.R1779G	DO229010	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.2222
p.R1779G	DO229016	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.2222
p.T1776I	DO229016	COCA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.1389
p.T1786S	DO233903	GACA	ICGC	AHTTS	DEG_SPOP_SBC_1	0.6005
p.T1786S	NCI-H661	lung	COSMIC	AHTTS	DEG_SPOP_SBC_1	0.6005
p.T1786S	ML-1	thyroid	COSMIC	AHTTS	DEG_SPOP_SBC_1	0.6005
p.A1783S	SIDM01118	Small Cell Lung Carcinoma	GDSC	AHTTS	DEG_SPOP_SBC_1	0.7588
p.A1783S	NCI-H740	lung	COSMIC	AHTTS	DEG_SPOP_SBC_1	0.7588
p.S1787L	ACH-000998	Colon/Colorectal Cancer	CCLE	AHTTS	DEG_SPOP_SBC_1	0.7667
p.S1787L	CW-2	large_intestine	COSMIC	AHTTS	DEG_SPOP_SBC_1	0.7667
p.T1785N	NCC010	kidney	COSMIC	AHTTS	DEG_SPOP_SBC_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2271:2275	AHTTS	SPOP	0.9813	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1783:1787	AHTTS	SPOP	0.8802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AHTTS

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of AHTTS