DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ALTTT
Uniprot ID:
A6NH13
Source protein:
Putative uncharacterized protein DNAJC9-AS1
Source gene:
DNAJC9-AS1
Class:
DEG_SPOP_SBC_1
Location:
99:103
E3 ligase:
SPOP
DEGRON score:
0.5288
ASA_SCORE:
45.1
COIL:
0.3872
CONS_SCORE:
1
DSS_SCORE:
0.6434
HELIX:
0.1078
FCONS_SCORE:
1.0476
RIG_SCORE:
0.7358
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DNAJC9-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ALTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N7E2
E3 ubiquitin-protein ligase CBLL2
DEG_SPOP_SBC_1
315:319
ALTTT
SPOP
0.9902
More...
A6NH13
Putative uncharacterized protein DNAJC9-AS1
DEG_SPOP_SBC_1
99:103
ALTTT
SPOP
0.5288
More...