DegronMD

Uniprot ID: Q8N7E2

Source protein: E3 ubiquitin-protein ligase CBLL2

Source gene: CBLL2

Class: DEG_SPOP_SBC_1

Location: 315:319

E3 ligase: SPOP

DEGRON score: 0.9902

ASA_SCORE: 81.86

COIL: 0.964

CONS_SCORE: 0.2586

DSS_SCORE: 0.5101

HELIX: 0.0138

FCONS_SCORE: 0.9971

RIG_SCORE: 0.7362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S308L	SIDM00889	Cervical Carcinoma	GDSC	ALTTT	DEG_SPOP_SBC_1	0.1389
p.S308L	C-33-A	cervix	COSMIC	ALTTT	DEG_SPOP_SBC_1	0.1389
p.Q312P	SIDM01140	Ovarian Carcinoma	GDSC	ALTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7E2	E3 ubiquitin-protein ligase CBLL2	DEG_SPOP_SBC_1	315:319	ALTTT	SPOP	0.9902	More...
A6NH13	Putative uncharacterized protein DNAJC9-AS1	DEG_SPOP_SBC_1	99:103	ALTTT	SPOP	0.5288	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons