DegronMD

Uniprot ID: P45984

Source protein: Mitogen-activated protein kinase 9

Source gene: MAPK9

Class: DEG_APCC_DBOX_1

Location: 294:302

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7236

ASA_SCORE: 27.0556

COIL: 0.0959

CONS_SCORE: 0.7256

DSS_SCORE: 0.2529

HELIX: 0.8871

FCONS_SCORE: 1.3492

RIG_SCORE: 0.8139

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V303L	TCGA-91-6836	LUAD	TCGA	ARDLLSKML	DEG_APCC_DBOX_1	0.3056
p.V303L	DO23854	LUAD	ICGC	ARDLLSKML	DEG_APCC_DBOX_1	0.3056
p.R309Q	TCGA-BP-4161	KIRC	TCGA	ARDLLSKML	DEG_APCC_DBOX_1	0.1389
p.R309Q	DO17769	KIRC	ICGC	ARDLLSKML	DEG_APCC_DBOX_1	0.1389
p.Q293E	TCGA-Q1-A73O	CESC	TCGA	ARDLLSKML	DEG_APCC_DBOX_1	0.3056
p.Q293E	DO51612	CESC	ICGC	ARDLLSKML	DEG_APCC_DBOX_1	0.3056
p.S311F	DO225136	BRCA	ICGC	ARDLLSKML	DEG_APCC_DBOX_1	0.5278
p.K300E	DO229211	THCA	ICGC	ARDLLSKML	DEG_APCC_DBOX_1	0.591
p.P306S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	ARDLLSKML	DEG_APCC_DBOX_1	0.2222
p.P306S	TE-4	oesophagus	COSMIC	ARDLLSKML	DEG_APCC_DBOX_1	0.2222
p.R286Q	SIDM00783	Colorectal Carcinoma	GDSC	ARDLLSKML	DEG_APCC_DBOX_1	0.1111
p.R286Q	ACH-000971	Colon/Colorectal Cancer	CCLE	ARDLLSKML	DEG_APCC_DBOX_1	0.1111
p.R286Q	HCT-116	large_intestine	COSMIC	ARDLLSKML	DEG_APCC_DBOX_1	0.1111
p.S307L	ACH-002309	Sarcoma	CCLE	ARDLLSKML	DEG_APCC_DBOX_1	0.1944
p.S307L	SW684	soft_tissue	COSMIC	ARDLLSKML	DEG_APCC_DBOX_1	0.1944

Drug responses associated with MAPK9 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.R286* (Yes)	GDSC	Doramapimod	26.7087
SIDM00499	PRAD\|prostate	p.T401A (No)	GDSC	JNK-9L	1.1662
SIDM00499	PRAD\|prostate	p.T401A (No)	GDSC	AS601245	19.3717
SIDM00499	PRAD\|prostate	p.T401A (No)	GDSC	AS601245	19.3717
SIDM00499	PRAD\|prostate	p.T401A (No)	GDSC	Doramapimod	54.6536
SIDM00353	UNCLASSIFIED\|ovary	p.V186L (No)	GDSC	JNK-9L	0.8498
SIDM00353	UNCLASSIFIED\|ovary	p.V186L (No)	GDSC	AS601245	8.4582
SIDM00353	UNCLASSIFIED\|ovary	p.V186L (No)	GDSC	AS601245	8.4582
SIDM00353	UNCLASSIFIED\|ovary	p.V186L (No)	GDSC	Doramapimod	33.4207
SIDM00250	ESCA\|oesophagus	p.P306S (Yes)	GDSC	Doramapimod	28.8203
SIDM00174	HNSC\|head_and_neck	p.K56N (No)	GDSC	JNK-9L	2.1292
SIDM00174	HNSC\|head_and_neck	p.K56N (No)	GDSC	AS601245	1.0969
SIDM00174	HNSC\|head_and_neck	p.K56N (No)	GDSC	AS601245	1.0969
SIDM00174	HNSC\|head_and_neck	p.K56N (No)	GDSC	Doramapimod	195.5074
SIDM00126	SKCM\|melanoma	p.D45E (No)	GDSC	JNK-9L	0.7862
SIDM00126	SKCM\|melanoma	p.D45E (No)	GDSC	AS601245	7.7158
SIDM00126	SKCM\|melanoma	p.D45E (No)	GDSC	AS601245	7.7158
SIDM00126	SKCM\|melanoma	p.D45E (No)	GDSC	Doramapimod	149.0053
SIDM00945	COREAD\|large_intestine	p.E109K (No)	GDSC	Doramapimod	255.1381
SIDM01168	OV\|ovary	p.K270N (No)	GDSC	JNK-9L	0.988
SIDM01168	OV\|ovary	p.K270N (No)	GDSC	AS601245	5.7487
SIDM01168	OV\|ovary	p.K270N (No)	GDSC	AS601245	5.7487
SIDM01168	OV\|ovary	p.K270N (No)	GDSC	Doramapimod	170.8174
SIDM00411	PAAD\|pancreas	p.K68N (No)	GDSC	JNK-9L	1.214
SIDM00411	PAAD\|pancreas	p.K68N (No)	GDSC	AS601245	212.6662
SIDM00411	PAAD\|pancreas	p.K68N (No)	GDSC	AS601245	212.6662
SIDM00411	PAAD\|pancreas	p.K68N (No)	GDSC	Doramapimod	177.3787
SIDM00042	PAAD\|pancreas	p.R366I (No)	GDSC	JNK-9L	0.7975
SIDM00042	PAAD\|pancreas	p.R366I (No)	GDSC	AS601245	12.6733
SIDM00042	PAAD\|pancreas	p.R366I (No)	GDSC	AS601245	12.6733
SIDM00042	PAAD\|pancreas	p.R366I (No)	GDSC	Doramapimod	21.1334
SIDM00425	OV\|ovary	p.S12G (No)	GDSC	JNK-9L	0.2206
SIDM00425	OV\|ovary	p.S12G (No)	GDSC	AS601245	1.242
SIDM00425	OV\|ovary	p.S12G (No)	GDSC	AS601245	1.242
SIDM00425	OV\|ovary	p.S12G (No)	GDSC	Doramapimod	32.0617
SIDM00807	BLCA\|bladder	p.L132V (No)	GDSC	JNK-9L	3.1768
SIDM00807	BLCA\|bladder	p.L132V (No)	GDSC	AS601245	6.1376
SIDM00807	BLCA\|bladder	p.L132V (No)	GDSC	AS601245	6.1376
SIDM00807	BLCA\|bladder	p.L132V (No)	GDSC	Doramapimod	80.1015
SIDM01217	ALL\|leukemia	p.S12G (No)	GDSC	JNK-9L	0.8681
SIDM01217	ALL\|leukemia	p.S12G (No)	GDSC	AS601245	3.1469
SIDM01217	ALL\|leukemia	p.S12G (No)	GDSC	AS601245	3.1469
SIDM00783	COREAD\|large_intestine	p.R286Q (Yes)	GDSC	JNK-9L	0.1883
SIDM00783	COREAD\|large_intestine	p.R286Q (Yes)	GDSC	AS601245	9.3792
SIDM00783	COREAD\|large_intestine	p.R286Q (Yes)	GDSC	AS601245	9.3792
SIDM00783	COREAD\|large_intestine	p.R286Q (Yes)	GDSC	Doramapimod	50.5657
SIDM01205	DLBC\|B_cell_lymphoma	p.N156S (No)	GDSC	JNK-9L	0.3385
SIDM01205	DLBC\|B_cell_lymphoma	p.N156S (No)	GDSC	AS601245	6.0161
SIDM01205	DLBC\|B_cell_lymphoma	p.N156S (No)	GDSC	AS601245	6.0161
SIDM01205	DLBC\|B_cell_lymphoma	p.N156S (No)	GDSC	Doramapimod	40.7839
SIDM00789	COREAD\|large_intestine	p.G227C (No)	GDSC	JNK-9L	0.3266
SIDM00789	COREAD\|large_intestine	p.G227C (No)	GDSC	AS601245	5.0705
SIDM00789	COREAD\|large_intestine	p.G227C (No)	GDSC	AS601245	5.0705
SIDM00789	COREAD\|large_intestine	p.G227C (No)	GDSC	Doramapimod	71.8805
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S392L (No)	GDSC	JNK-9L	2.7334
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S392L (No)	GDSC	AS601245	292.0383
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S392L (No)	GDSC	AS601245	292.0383
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S392L (No)	GDSC	Doramapimod	374.0169
SIDM00545	SKCM\|melanoma	p.R59C (No)	GDSC	JNK-9L	0.9396
SIDM00545	SKCM\|melanoma	p.R59C (No)	GDSC	AS601245	35.0042
SIDM00545	SKCM\|melanoma	p.R59C (No)	GDSC	AS601245	35.0042
SIDM00545	SKCM\|melanoma	p.R59C (No)	GDSC	Doramapimod	100.1926
SIDM00114	MESO\|mesothelioma	p.G146V (No)	GDSC	JNK-9L	4.8308
SIDM00114	MESO\|mesothelioma	p.G146V (No)	GDSC	AS601245	227.6262
SIDM00114	MESO\|mesothelioma	p.G146V (No)	GDSC	AS601245	227.6262
SIDM00114	MESO\|mesothelioma	p.G146V (No)	GDSC	Doramapimod	408.498
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.E365K (No)	GDSC	JNK-9L	0.0989
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.E365K (No)	GDSC	AS601245	2.6069
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.E365K (No)	GDSC	AS601245	2.6069
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.E365K (No)	GDSC	Doramapimod	44.2974
SIDM01259	ALL\|lymphoblastic_leukemia	p.T188S (No)	GDSC	JNK-9L	0.8216
SIDM01259	ALL\|lymphoblastic_leukemia	p.T188S (No)	GDSC	AS601245	7.9967
SIDM01259	ALL\|lymphoblastic_leukemia	p.T188S (No)	GDSC	AS601245	7.9967
SIDM01259	ALL\|lymphoblastic_leukemia	p.T188S (No)	GDSC	Doramapimod	299.4259
SIDM00374	DLBC\|B_cell_lymphoma	p.S12G (No)	GDSC	JNK-9L	0.7314
SIDM00374	DLBC\|B_cell_lymphoma	p.S12G (No)	GDSC	AS601245	4.1677
SIDM00374	DLBC\|B_cell_lymphoma	p.S12G (No)	GDSC	AS601245	4.1677
SIDM00374	DLBC\|B_cell_lymphoma	p.S12G (No)	GDSC	Doramapimod	101.2366
SIDM00118	COREAD\|large_intestine	p.F248L (No)	GDSC	JNK-9L	1.0193
SIDM00118	COREAD\|large_intestine	p.F248L (No)	GDSC	AS601245	2.456
SIDM00118	COREAD\|large_intestine	p.F248L (No)	GDSC	AS601245	2.456
SIDM00118	COREAD\|large_intestine	p.F248L (No)	GDSC	Doramapimod	47.574

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P45984	Mitogen-activated protein kinase 9	DEG_APCC_DBOX_1	294:302	ARDLLSKML	APC,CDC20,FZR1	0.7236	More...
P53779	Mitogen-activated protein kinase 10	DEG_APCC_DBOX_1	332:340	ARDLLSKML	APC,CDC20,FZR1	0.7531	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARDLLSKML

Degron related mutations and impact score

Drug responses associated with MAPK9 mutations

All proteins holding degron of ARDLLSKML