DegronMD

Uniprot ID: P53779

Source protein: Mitogen-activated protein kinase 10

Source gene: MAPK10

Class: DEG_APCC_DBOX_1

Location: 332:340

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7531

ASA_SCORE: 24.7222

COIL: 0.092

CONS_SCORE: 0.8151

DSS_SCORE: 0.2064

HELIX: 0.8914

FCONS_SCORE: 1.3946

RIG_SCORE: 0.809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E323D	TCGA-AA-A010	COAD	TCGA	ARDLLSKML	DEG_APCC_DBOX_1	0.0833
p.A332V	TCGA-AX-A0J1	UCEC	TCGA	ARDLLSKML	DEG_APCC_DBOX_1	0.5825
p.E323K	SIDM01086	B-Lymphoblastic Leukemia	GDSC	ARDLLSKML	DEG_APCC_DBOX_1	0.0833
p.E323K	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	ARDLLSKML	DEG_APCC_DBOX_1	0.0833
p.N322S	ACH-001656	Leukemia	CCLE	ARDLLSKML	DEG_APCC_DBOX_1	0.0556
p.W324S	ACH-002305	Head and Neck Cancer	CCLE	ARDLLSKML	DEG_APCC_DBOX_1	0.1111
p.W324S	SKN-3	upper_aerodigestive_tract	COSMIC	ARDLLSKML	DEG_APCC_DBOX_1	0.1111
p.S323F	KYSE-150	oesophagus	COSMIC	ARDLLSKML	DEG_APCC_DBOX_1	0.0833
p.E326K	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	ARDLLSKML	DEG_APCC_DBOX_1	0.2778

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01031	ESCA\|oesophagus	p.S437F (No)	GDSC	JNK-9L	0.6229
SIDM00688	DLBC\|B_cell_lymphoma	p.D87H (No)	GDSC	JNK-9L	0.5478
SIDM01086	ALL\|leukemia	p.E323K (Yes)	GDSC	JNK-9L	0.3603
SIDM01237	LIHC\|liver	p.F318Y (No)	GDSC	JNK-9L	0.4007
SIDM00602	STAD\|stomach	p.A231T (No)	GDSC	JNK-9L	0.2782
SIDM01028	ESCA\|oesophagus	p.S40R (No)	GDSC	JNK-9L	0.6068
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.E425* (No)	GDSC	JNK-9L	0.2887
SIDM00660	COREAD\|large_intestine	p.T145I (No)	GDSC	JNK-9L	0.1886
SIDM01206	NB\|neuroblastoma	p.I124M (No)	GDSC	JNK-9L	0.5419
SIDM00375	HNSC\|head_and_neck	p.W362S (No)	GDSC	JNK-9L	0.8285
SIDM00963	BRCA\|breast	p.R88K (No)	GDSC	JNK-9L	1.0658
SIDM00581	GBM\|glioma	p.T135M (No)	GDSC	JNK-9L	0.2707
SIDM00837	COREAD\|large_intestine	p.K191N (No)	GDSC	JNK-9L	0.4124
SIDM00118	COREAD\|large_intestine	p.D421G (No)	GDSC	JNK-9L	1.0193

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P45984	Mitogen-activated protein kinase 9	DEG_APCC_DBOX_1	294:302	ARDLLSKML	APC,CDC20,FZR1	0.7236	More...
P53779	Mitogen-activated protein kinase 10	DEG_APCC_DBOX_1	332:340	ARDLLSKML	APC,CDC20,FZR1	0.7531	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons