DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
CPSAQVSPA
Uniprot ID:
Q902F8
Source protein:
Endogenous retrovirus group K member 8 Env polyprotein
Source gene:
ERVK-8
Class:
DEG_SIAH_1
Location:
282:290
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.9551
ASA_SCORE:
49.9556
COIL:
0.789
CONS_SCORE:
0.2152
DSS_SCORE:
0.4708
HELIX:
0.0992
FCONS_SCORE:
1.308
RIG_SCORE:
0.6755
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ERVK-8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of CPSAQVSPA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q69384
Endogenous retrovirus group K member 6 Env polyprotein
DEG_SIAH_1
282:290
CPSAQVSPA
SIAH1,SIAH2,SIAH3
0.9623
More...
O71037
Endogenous retrovirus group K member 19 Env polyprotein
DEG_SIAH_1
282:290
CPSAQVSPA
SIAH1,SIAH2,SIAH3
0.9551
More...
P61565
Endogenous retrovirus group K member 21 Env polyprotein
DEG_SIAH_1
281:289
CPSAQVSPA
SIAH1,SIAH2,SIAH3
0.9623
More...
P61566
Endogenous retrovirus group K member 24 Env polyprotein
DEG_SIAH_1
171:179
CPSAQVSPA
SIAH1,SIAH2,SIAH3
0.9511
More...
P61567
Endogenous retrovirus group K member 7 Env polyprotein
DEG_SIAH_1
171:179
CPSAQVSPA
SIAH1,SIAH2,SIAH3
0.7111
More...
Q902F8
Endogenous retrovirus group K member 8 Env polyprotein
DEG_SIAH_1
282:290
CPSAQVSPA
SIAH1,SIAH2,SIAH3
0.9551
More...
Q902F9
Endogenous retrovirus group K member 113 Env polyprotein
DEG_SIAH_1
282:290
CPSAQVSPA
SIAH1,SIAH2,SIAH3
0.8831
More...
Q9UKH3
Endogenous retrovirus group K member 9 Env polyprotein
DEG_SIAH_1
281:289
CPSAQVSPA
SIAH1,SIAH2,SIAH3
0.9581
More...
P61570
Endogenous retrovirus group K member 25 Env polyprotein
DEG_SIAH_1
282:290
CPSAQVSPA
SIAH1,SIAH2,SIAH3
0.9532
More...