DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DDKGAYSVGP
Uniprot ID:
Q15155
Source protein:
Nodal modulator 1
Source gene:
NOMO1
Class:
CBL_PTK
Location:
833:842
E3 ligase:
CBL
DEGRON score:
0.7422
ASA_SCORE:
62.43
COIL:
0.673
CONS_SCORE:
0.609
DSS_SCORE:
0.2587
HELIX:
0.0112
FCONS_SCORE:
1.2523
RIG_SCORE:
0.7566
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V830I
TCGA-AA-A01Z
COAD
TCGA
DDKGAYSVGP
CBL_PTK
0.25
p.V830I
DO8392
COAD
ICGC
DDKGAYSVGP
CBL_PTK
0.25
p.P842S
TCGA-AM-5821
COAD
TCGA
DDKGAYSVGP
CBL_PTK
0.6752
p.P842S
DO8240
COAD
ICGC
DDKGAYSVGP
CBL_PTK
0.6752
p.H844Y
SIDM00228
Thyroid Gland Carcinoma
GDSC
DDKGAYSVGP
CBL_PTK
0.2778
p.H844Y
ACH-000897
Thyroid Cancer
CCLE
DDKGAYSVGP
CBL_PTK
0.2778
Drug responses associated with NOMO1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DDKGAYSVGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15155
Nodal modulator 1
CBL_PTK
833:842
DDKGAYSVGP
CBL
0.7422
More...
Q5JPE7
Nodal modulator 2
CBL_PTK
833:842
DDKGAYSVGP
CBL
0.6202
More...
P69849
Nodal modulator 3
CBL_PTK
833:842
DDKGAYSVGP
CBL
0.6202
More...
