DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DDKGAYSVGP
Uniprot ID:
Q5JPE7
Source protein:
Nodal modulator 2
Source gene:
NOMO2
Class:
CBL_PTK
Location:
833:842
E3 ligase:
CBL
DEGRON score:
0.6202
ASA_SCORE:
57.22
COIL:
0.6463
CONS_SCORE:
0.6076
DSS_SCORE:
0.2587
HELIX:
0.0115
FCONS_SCORE:
1.2514
RIG_SCORE:
0.7566
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NOMO2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DDKGAYSVGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15155
Nodal modulator 1
CBL_PTK
833:842
DDKGAYSVGP
CBL
0.7422
More...
Q5JPE7
Nodal modulator 2
CBL_PTK
833:842
DDKGAYSVGP
CBL
0.6202
More...
P69849
Nodal modulator 3
CBL_PTK
833:842
DDKGAYSVGP
CBL
0.6202
More...
