DegronMD

Uniprot ID: Q9H2A2

Source protein: 2-aminomuconic semialdehyde dehydrogenase

Source gene: ALDH8A1

Class: DEG_Kelch_Keap1_1

Location: 29:34

E3 ligase: KEAP1

DEGRON score: 0.8347

ASA_SCORE: 49.15

COIL: 0.8977

CONS_SCORE: 0.6714

DSS_SCORE: 0.2376

HELIX: 0.0083

FCONS_SCORE: 1.19

RIG_SCORE: 0.7369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S22I	TCGA-17-Z052	LUAD	TCGA	DPSTGE	DEG_Kelch_Keap1_1	0.1389
p.T32A	TCGA-92-7341	LUSC	TCGA	DPSTGE	DEG_Kelch_Keap1_1	0.7139
p.T32A	DO26677	LUSC	ICGC	DPSTGE	DEG_Kelch_Keap1_1	0.7139
p.N41T	TCGA-A5-A0G1	UCEC	TCGA	DPSTGE	DEG_Kelch_Keap1_1	0.1389
p.N41T	DO42472	UCEC	ICGC	DPSTGE	DEG_Kelch_Keap1_1	0.1389
p.C21R	TCGA-BR-6452	STAD	TCGA	DPSTGE	DEG_Kelch_Keap1_1	0.1111
p.C21R	DO38404	STAD	ICGC	DPSTGE	DEG_Kelch_Keap1_1	0.1111
p.D29N	TCGA-ND-A4WC	UCS	TCGA	DPSTGE	DEG_Kelch_Keap1_1	0.5821
p.S23L	TCGA-Z2-A8RT	SKCM	TCGA	DPSTGE	DEG_Kelch_Keap1_1	0.1667
p.S23L	DO51301	SKCM	ICGC	DPSTGE	DEG_Kelch_Keap1_1	0.1667
p.P40L	DO228483	BRCA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	0.1667
p.S27F	DO233621	GACA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	0.2778
p.G33W	SIDM01183	Other Solid Cancers	GDSC	DPSTGE	DEG_Kelch_Keap1_1	0.7825
p.G33W	ACH-001417	Lung Cancer	CCLE	DPSTGE	DEG_Kelch_Keap1_1	0.7825
p.G33W	UMC-11	lung	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	0.7825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13501	Sequestosome-1	DEG_Kelch_Keap1_1	347:352	DPSTGE	KEAP1	0.9989	More...
Q15149	Plectin	DEG_Kelch_Keap1_1	3320:3325	DPSTGE	KEAP1	0.9965	More...
Q15149	Plectin	DEG_Kelch_Keap1_1	4460:4465	DPSTGE	KEAP1	0.9763	More...
Q9H2A2	2-aminomuconic semialdehyde dehydrogenase	DEG_Kelch_Keap1_1	29:34	DPSTGE	KEAP1	0.8347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons