DegronMD

Uniprot ID: Q15047

Source protein: Histone-lysine N-methyltransferase SETDB1

Source gene: SETDB1

Class: DEG_SCF_TRCP1_1

Location: 136:142

E3 ligase: BTRC

DEGRON score: 0.9477

ASA_SCORE: 67.9857

COIL: 0.8406

CONS_SCORE: 0.346

DSS_SCORE: 0.681

HELIX: 0.0984

FCONS_SCORE: 0.8863

RIG_SCORE: 0.6083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V132G	TCGA-A5-A0G2	UCEC	TCGA	DSGDAGS	DEG_SCF_TRCP1_1	0.2222
p.V132G	DO41235	UCEC	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.2222
p.R151C	TCGA-DF-A2KZ	UCEC	TCGA	DSGDAGS	DEG_SCF_TRCP1_1	0.0833
p.R151C	TCGA-EE-A2MJ	SKCM	TCGA	DSGDAGS	DEG_SCF_TRCP1_1	0.0833
p.R151C	DO38099	SKCM	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.0833
p.R151C	DO52409	UCEC	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.0833
p.D131G	DO224763	BRCA	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.1944
p.S142I	DO228952	LICA	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.7341
p.S134I	DO228976	LICA	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.7222
p.I135V	SIDM01033	Bladder Carcinoma	GDSC	DSGDAGS	DEG_SCF_TRCP1_1	0.3056
p.I135V	ACH-000486	Bladder Cancer	CCLE	DSGDAGS	DEG_SCF_TRCP1_1	0.3056
p.I135V	KU-19-19	urinary_tract	COSMIC	DSGDAGS	DEG_SCF_TRCP1_1	0.3056
p.L150I	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDAGS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15047	Histone-lysine N-methyltransferase SETDB1	DEG_SCF_TRCP1_1	136:142	DSGDAGS	BTRC	0.9477	More...
Q8IV56	Proline-rich protein 15	DEG_SCF_TRCP1_1	3:9	DSGDAGS	BTRC	0.9379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons