DegronMD

Uniprot ID: Q8IV56

Source protein: Proline-rich protein 15

Source gene: PRR15

Class: DEG_SCF_TRCP1_1

Location: 3:9

E3 ligase: BTRC

DEGRON score: 0.9379

ASA_SCORE: 75.7143

COIL: 0.884

CONS_SCORE: 0.5799

DSS_SCORE: 0.7689

HELIX: 0.1094

FCONS_SCORE: 0.7361

RIG_SCORE: 0.6034

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W13R	TCGA-44-6776	LUAD	TCGA	DSGDAGS	DEG_SCF_TRCP1_1	0.2222
p.W13R	DO24060	LUAD	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.2222
p.D6E	DO223036	ESCA	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.5647
p.W13C	DO44919	LIHC	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.2222
p.G5S	DO38404	STAD	ICGC	DSGDAGS	DEG_SCF_TRCP1_1	0.6993
p.S4G	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGDAGS	DEG_SCF_TRCP1_1	0.8104

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15047	Histone-lysine N-methyltransferase SETDB1	DEG_SCF_TRCP1_1	136:142	DSGDAGS	BTRC	0.9477	More...
Q8IV56	Proline-rich protein 15	DEG_SCF_TRCP1_1	3:9	DSGDAGS	BTRC	0.9379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons