DegronMD

Uniprot ID: Q6NUM6

Source protein: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B

Source gene: TYW1B

Class: DEG_SCF_TRCP1_1

Location: 620:626

E3 ligase: BTRC

DEGRON score: 0.7036

ASA_SCORE: 81.3429

COIL: 0.8181

CONS_SCORE: 0.2969

DSS_SCORE: 0.3001

HELIX: 0.1637

FCONS_SCORE: 0.6145

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K630N	SIDM01588	Endometrial Carcinoma	GDSC	DSGGSKT	DEG_SCF_TRCP1_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NUM6	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B	DEG_SCF_TRCP1_1	620:626	DSGGSKT	BTRC	0.7036	More...
Q9NV66	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1	DEG_SCF_TRCP1_1	684:690	DSGGSKT	BTRC	0.7036	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons