DegronMD

Uniprot ID: P11464

Source protein: Pregnancy-specific beta-1-glycoprotein 1

Source gene: PSG1

Class: LIG_APCC_ABBA_1

Location: 140:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6808

ASA_SCORE: 53.8667

COIL: 0.5088

CONS_SCORE: 0.5538

DSS_SCORE: 0.4423

HELIX: 0.0155

FCONS_SCORE: 1.2319

RIG_SCORE: 0.8244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F140I	TCGA-50-8457	LUAD	TCGA	FTLHLE	LIG_APCC_ABBA_1	0.6304
p.F140I	DO218927	LUAD	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.6304
p.G130A	TCGA-CG-4438	STAD	TCGA	FTLHLE	LIG_APCC_ABBA_1	0.0556
p.G130A	DO38280	STAD	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.0556
p.E145G	TCGA-D9-A6EC	SKCM	TCGA	FTLHLE	LIG_APCC_ABBA_1	0.7199
p.E145G	DO50291	SKCM	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.7199
p.E145D	TCGA-FD-A3SR	BLCA	TCGA	FTLHLE	LIG_APCC_ABBA_1	0.5647
p.E145D	DO810	BLCA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.5647
p.S154N	TCGA-VQ-A94U	STAD	TCGA	FTLHLE	LIG_APCC_ABBA_1	0.0833
p.S154N	DO222378	STAD	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.0833
p.R137P	DO225002	BRCA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.25
p.R137P	SIDM00557	Neuroblastoma	GDSC	FTLHLE	LIG_APCC_ABBA_1	0.25
p.R137P	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	FTLHLE	LIG_APCC_ABBA_1	0.25
p.H143Y	DO228950	LICA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.6118
p.H143Y	DO229053	LICA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.6118
p.H143Y	SIDM01265	Plasma Cell Myeloma	GDSC	FTLHLE	LIG_APCC_ABBA_1	0.6118
p.H143Y	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	FTLHLE	LIG_APCC_ABBA_1	0.6118
p.R137S	DO229018	LICA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.25
p.T139I	DO27847	MALY	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.3056
p.N155T	DO32980	PACA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.0556
p.T135A	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	FTLHLE	LIG_APCC_ABBA_1	0.1944
p.T135A	ACH-000727	Lung Cancer	CCLE	FTLHLE	LIG_APCC_ABBA_1	0.1944
p.T135A	NCI-H2066	lung	COSMIC	FTLHLE	LIG_APCC_ABBA_1	0.1944
p.G130R	NCI-H630	large_intestine	COSMIC	FTLHLE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	LIG_APCC_ABBA_1	140:145	FTLHLE	APC,CDC20,FZR1	0.6808	More...
Q00888	Pregnancy-specific beta-1-glycoprotein 4	LIG_APCC_ABBA_1	140:145	FTLHLE	APC,CDC20,FZR1	0.6237	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons