DegronMD

Uniprot ID: Q00888

Source protein: Pregnancy-specific beta-1-glycoprotein 4

Source gene: PSG4

Class: LIG_APCC_ABBA_1

Location: 140:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6237

ASA_SCORE: 61.5167

COIL: 0.5982

CONS_SCORE: 0.4387

DSS_SCORE: 0.4179

HELIX: 0.049

FCONS_SCORE: 1.0536

RIG_SCORE: 0.8217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H143Q	TCGA-44-3398	LUAD	TCGA	FTLHLE	LIG_APCC_ABBA_1	0.7582
p.H143Q	DO25030	LUAD	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.7582
p.T141N	TCGA-EB-A85J	SKCM	TCGA	FTLHLE	LIG_APCC_ABBA_1	0.5944
p.T141N	DO50297	SKCM	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.5944
p.G136E	TCGA-FS-A1ZW	SKCM	TCGA	FTLHLE	LIG_APCC_ABBA_1	0.2222
p.G136E	DO37519	SKCM	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.2222
p.S152F	TCGA-OD-A75X	SKCM	TCGA	FTLHLE	LIG_APCC_ABBA_1	0.1389
p.S152F	DO229459	SKCA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.1389
p.S152F	DO229462	SKCA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.1389
p.S152F	DO48601	SKCM	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.1389
p.K145Q	DO8264	COAD	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.6944
p.V134I	DO233650	GACA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.1667
p.H143Y	DO228950	LICA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.6118
p.H143Y	DO229061	LICA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.6118
p.T139N	DO228971	LICA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.3056
p.H137Y	DO229052	LICA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.25
p.G133E	DO220873	MELA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.1389
p.L144P	DO220906	MELA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.6471
p.N155D	DO232445	PBCA	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.0556
p.I153T	DO42312	UCEC	ICGC	FTLHLE	LIG_APCC_ABBA_1	0.1111
p.S153R	SIDM00135	Breast Carcinoma	GDSC	FTLHLE	LIG_APCC_ABBA_1	0.1111
p.S153R	ACH-000148	Breast Cancer	CCLE	FTLHLE	LIG_APCC_ABBA_1	0.1111
p.S153R	ACH-000532	Colon/Colorectal Cancer	CCLE	FTLHLE	LIG_APCC_ABBA_1	0.1111
p.S153R	Hs-578-T	breast	COSMIC	FTLHLE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	LIG_APCC_ABBA_1	140:145	FTLHLE	APC,CDC20,FZR1	0.6808	More...
Q00888	Pregnancy-specific beta-1-glycoprotein 4	LIG_APCC_ABBA_1	140:145	FTLHLE	APC,CDC20,FZR1	0.6237	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons