DegronMD

Uniprot ID: O43293

Source protein: Death-associated protein kinase 3

Source gene: DAPK3

Class: DEG_APCC_TPR_1

Location: 452:454

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9358

ASA_SCORE: 113.6333

COIL: 0.865

CONS_SCORE: 0.2992

DSS_SCORE: 0.7466

HELIX: 0.1023

FCONS_SCORE: 1.0262

RIG_SCORE: 0.7746

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00499	PRAD\|prostate	p.I168T (No)	GDSC	PI-103	0.3537
SIDM00859	DLBC\|B_cell_lymphoma	p.I307T (No)	GDSC	PI-103	0.0793
SIDM00370	ALL\|lymphoblastic_T_cell_leukaemia	p.G36fs*17 (No)	GDSC	PI-103	16.4212
SIDM00217	COREAD\|large_intestine	p.R156* (No)	GDSC	PI-103	1.8634
SIDM00217	COREAD\|large_intestine	p.F24L (No)	GDSC	PI-103	1.8634
SIDM00282	COREAD\|large_intestine	p.R411H (No)	GDSC	PI-103	28.6572
SIDM00737	UNCLASSIFIED\|lung_NSCLC_not_specified	p.P216S (No)	GDSC	PI-103	134.5226
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.G36D (No)	GDSC	PI-103	0.976
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.V27M (No)	GDSC	PI-103	0.976
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.G213S (No)	GDSC	PI-103	0.069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43293	Death-associated protein kinase 3	DEG_APCC_TPR_1	452:454	GLR	APC,CDC20,FZR1	0.9358	More...
P17026	Zinc finger protein 22	DEG_APCC_TPR_1	222:224	GLR	APC,CDC20,FZR1	0.7778	More...
Q9BTD8	RNA-binding protein 42	DEG_APCC_TPR_1	478:480	GLR	APC,CDC20,FZR1	0.9441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons