DegronMD

Uniprot ID: Q9BTD8

Source protein: RNA-binding protein 42

Source gene: RBM42

Class: DEG_APCC_TPR_1

Location: 478:480

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9441

ASA_SCORE: 133.1333

COIL: 0.9777

CONS_SCORE: 0.4093

DSS_SCORE: 0.955

HELIX: 0.025

FCONS_SCORE: 0.8249

RIG_SCORE: 0.7321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q471H	TCGA-AP-A1E0	UCEC	TCGA	GLR	DEG_APCC_TPR_1	0.1389
p.R468H	TCGA-BR-8372	STAD	TCGA	GLR	DEG_APCC_TPR_1	0.0556
p.K476E	TCGA-DI-A1BU	UCEC	TCGA	GLR	DEG_APCC_TPR_1	0.2778
p.G478C	SIDM00585	Hepatocellular Carcinoma	GDSC	GLR	DEG_APCC_TPR_1	0.6489
p.G478C	ACH-000480	Liver Cancer	CCLE	GLR	DEG_APCC_TPR_1	0.6489
p.G478C	HuH-7	liver	COSMIC	GLR	DEG_APCC_TPR_1	0.6489

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43293	Death-associated protein kinase 3	DEG_APCC_TPR_1	452:454	GLR	APC,CDC20,FZR1	0.9358	More...
P17026	Zinc finger protein 22	DEG_APCC_TPR_1	222:224	GLR	APC,CDC20,FZR1	0.7778	More...
Q9BTD8	RNA-binding protein 42	DEG_APCC_TPR_1	478:480	GLR	APC,CDC20,FZR1	0.9441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons