DegronMD

Uniprot ID: P17026

Source protein: Zinc finger protein 22

Source gene: ZNF22

Class: DEG_APCC_TPR_1

Location: 222:224

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7778

ASA_SCORE: 97.5333

COIL: 0.8747

CONS_SCORE: 0.6566

DSS_SCORE: 0.9427

HELIX: 0.0877

FCONS_SCORE: 0.8819

RIG_SCORE: 0.7261

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R224H	TCGA-AX-A3G8	UCEC	TCGA	GLR	DEG_APCC_TPR_1	0.8244
p.R224H	DO222769	COCA	ICGC	GLR	DEG_APCC_TPR_1	0.8244
p.R224H	DO41014	UCEC	ICGC	GLR	DEG_APCC_TPR_1	0.8244
p.L223I	TCGA-EO-A22T	UCEC	TCGA	GLR	DEG_APCC_TPR_1	0.6063
p.L223I	DO42320	UCEC	ICGC	GLR	DEG_APCC_TPR_1	0.6063
p.R224C	DO229446	SKCA	ICGC	GLR	DEG_APCC_TPR_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43293	Death-associated protein kinase 3	DEG_APCC_TPR_1	452:454	GLR	APC,CDC20,FZR1	0.9358	More...
P17026	Zinc finger protein 22	DEG_APCC_TPR_1	222:224	GLR	APC,CDC20,FZR1	0.7778	More...
Q9BTD8	RNA-binding protein 42	DEG_APCC_TPR_1	478:480	GLR	APC,CDC20,FZR1	0.9441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons