DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
GREPLLVVK
Uniprot ID:
A6NE21
Source protein:
Source gene:
-
Class:
DEG_APCC_DBOX_1
Location:
219:227
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8186
ASA_SCORE:
82.5111
COIL:
0.8118
CONS_SCORE:
0.2568
DSS_SCORE:
0.7163
HELIX:
0.0507
FCONS_SCORE:
1.0476
RIG_SCORE:
0.681
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with - mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GREPLLVVK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NE21
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8186
More...
A6NEW6
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.7699
More...
A6NJQ4
Putative protein FAM90A8
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.6416
More...
A6NNJ1
Putative protein FAM90A9
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.9698
More...
A8MX19
Putative protein FAM90A12P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.558
More...
A8MXJ8
Putative protein FAM90A5P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8433
More...
A8MXZ1
Putative protein FAM90A23
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8338
More...
P0C7V4
Putative protein FAM90A15P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8338
More...
P0C7W8
Putative protein FAM90A13P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8338
More...
P0C7W9
Putative protein FAM90A14
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.5437
More...
P0C7X0
Putative protein FAM90A24P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8338
More...