DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
GREPLLVVK
Uniprot ID:
P0C7V4
Source protein:
Putative protein FAM90A15P
Source gene:
FAM90A15P
Class:
DEG_APCC_DBOX_1
Location:
219:227
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8338
ASA_SCORE:
77.4
COIL:
0.7799
CONS_SCORE:
0.1554
DSS_SCORE:
0.7163
HELIX:
0.0821
FCONS_SCORE:
0.9811
RIG_SCORE:
0.6863
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM90A15P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GREPLLVVK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NE21
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8186
More...
A6NEW6
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.7699
More...
A6NJQ4
Putative protein FAM90A8
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.6416
More...
A6NNJ1
Putative protein FAM90A9
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.9698
More...
A8MX19
Putative protein FAM90A12P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.558
More...
A8MXJ8
Putative protein FAM90A5P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8433
More...
A8MXZ1
Putative protein FAM90A23
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8338
More...
P0C7V4
Putative protein FAM90A15P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8338
More...
P0C7W8
Putative protein FAM90A13P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8338
More...
P0C7W9
Putative protein FAM90A14
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.5437
More...
P0C7X0
Putative protein FAM90A24P
DEG_APCC_DBOX_1
219:227
GREPLLVVK
APC,CDC20,FZR1
0.8338
More...