DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 1545:1550

E3 ligase: FBXW7

DEGRON score: 0.8621

ASA_SCORE: 94.0333

COIL: 0.9282

CONS_SCORE: 0.1868

DSS_SCORE: 0.7551

HELIX: 0.0103

FCONS_SCORE: 0.9817

RIG_SCORE: 0.6291

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1548S	TCGA-EE-A29M	SKCM	TCGA	ITPNPT	DEG_SCF_FBW7_1	0.5958
p.N1548S	DO37404	SKCM	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.5958
p.T1544M	DO222765	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.3056
p.R1555G	DO222894	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1555G	DO229010	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1555G	DO229013	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1555G	DO229016	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1555G	DO229003	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1555G	DO229005	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1555G	DO233074	GACA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1555G	DO51040	LAML	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1555G	DO52389	LUSC	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1555G	DO229234	THCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1944
p.R1553G	DO229010	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO229013	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO229016	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO229003	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO229005	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO233074	GACA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO51040	LAML	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO51028	LAML	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO51004	LAML	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO52377	LUSC	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO52391	LUSC	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO52389	LUSC	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO229180	THCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO229199	THCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO229234	THCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.R1553G	DO229248	THCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.25
p.S1551R	DO233941	GACA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.3056
p.T1556I	DO231114	LUSC	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1667
p.T1556N	SIDM00350	Head and Neck Carcinoma	GDSC	ITPNPT	DEG_SCF_FBW7_1	0.1667
p.T1556N	SIDM00018	Acute Myeloid Leukemia	GDSC	ITPNPT	DEG_SCF_FBW7_1	0.1667
p.T1556N	ACH-000498	Leukemia	CCLE	ITPNPT	DEG_SCF_FBW7_1	0.1667
p.T1556N	ACH-001641	Head and Neck Cancer	CCLE	ITPNPT	DEG_SCF_FBW7_1	0.1667
p.T1556N	ACH-002046	Endometrial/Uterine Cancer	CCLE	ITPNPT	DEG_SCF_FBW7_1	0.1667
p.T1556N	ACH-002065	Sarcoma	CCLE	ITPNPT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPNPT

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of ITPNPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1545:1550	ITPNPT	FBXW7	0.8621	More...
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1714:1719	ITPNPT	FBXW7	0.7983	More...