DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 1714:1719

E3 ligase: FBXW7

DEGRON score: 0.7983

ASA_SCORE: 96.9333

COIL: 0.9552

CONS_SCORE: 0.1903

DSS_SCORE: 0.7206

HELIX: 0.0105

FCONS_SCORE: 0.9249

RIG_SCORE: 0.6137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1705K	TCGA-FW-A3R5	SKCM	TCGA	ITPNPT	DEG_SCF_FBW7_1	0.0833
p.E1705K	DO37406	SKCM	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.0833
p.P1716S	DO228483	BRCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO224820	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO222762	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO222793	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO222894	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO222829	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO229346	LAML	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO50986	LAML	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO51031	LAML	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO228390	LICA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO228589	LICA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.P1716S	DO52389	LUSC	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.6752
p.M1726I	DO224801	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1389
p.A1704P	DO222746	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.0556
p.A1704P	DO222835	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.0556
p.A1704P	DO229016	COCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.0556
p.A1704P	DO52338	LUSC	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.0556
p.P1725L	DO50970	LICA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.1667
p.T1715A	DO45299	LIRI	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.7139
p.P1718S	DO51483	PACA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.5641
p.T1723P	DO229453	SKCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.2222
p.N1717T	DO218908	SKCA	ICGC	ITPNPT	DEG_SCF_FBW7_1	0.5944
p.T1715I	SIDM00719	Small Cell Lung Carcinoma	GDSC	ITPNPT	DEG_SCF_FBW7_1	0.7078
p.T1715I	NCI-H345	lung	COSMIC	ITPNPT	DEG_SCF_FBW7_1	0.7078
p.P1716R	SIDM01391	Neuroblastoma	GDSC	ITPNPT	DEG_SCF_FBW7_1	0.7512
p.N1713T	BE2-M17	autonomic_ganglia	COSMIC	ITPNPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1545:1550	ITPNPT	FBXW7	0.8621	More...
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1714:1719	ITPNPT	FBXW7	0.7983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPNPT

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of ITPNPT