DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPFSE
Uniprot ID:
Q6NSW5
Source protein:
Putative DENN domain-containing protein 10 B
Source gene:
DENND10P1
Class:
LIG_APCC_ABBA_1
Location:
312:317
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6406
ASA_SCORE:
47.1167
COIL:
0.2365
CONS_SCORE:
0.5269
DSS_SCORE:
0.3029
HELIX:
0.7135
FCONS_SCORE:
1.1596
RIG_SCORE:
0.7752
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DENND10P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPFSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TCE6
DENN domain-containing protein 10
LIG_APCC_ABBA_1
312:317
LAPFSE
APC,CDC20,FZR1
0.7008
More...
Q6NSW5
Putative DENN domain-containing protein 10 B
LIG_APCC_ABBA_1
312:317
LAPFSE
APC,CDC20,FZR1
0.6406
More...