DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPFSE
Uniprot ID:
Q8TCE6
Source protein:
DENN domain-containing protein 10
Source gene:
DENND10
Class:
LIG_APCC_ABBA_1
Location:
312:317
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7008
ASA_SCORE:
48.95
COIL:
0.2658
CONS_SCORE:
0.5269
DSS_SCORE:
0.295
HELIX:
0.6637
FCONS_SCORE:
1.1597
RIG_SCORE:
0.7767
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DENND10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPFSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TCE6
DENN domain-containing protein 10
LIG_APCC_ABBA_1
312:317
LAPFSE
APC,CDC20,FZR1
0.7008
More...
Q6NSW5
Putative DENN domain-containing protein 10 B
LIG_APCC_ABBA_1
312:317
LAPFSE
APC,CDC20,FZR1
0.6406
More...