DegronMD

Uniprot ID: P43699

Source protein: Homeobox protein Nkx-2.1

Source gene: NKX2-1

Class: LIG_APCC_ABBA_1

Location: 97:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8332

ASA_SCORE: 40.2167

COIL: 0.8308

CONS_SCORE: 0.4973

DSS_SCORE: 0.5174

HELIX: 0.1193

FCONS_SCORE: 0.9883

RIG_SCORE: 0.7487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S109L	TCGA-98-A53J	LUSC	TCGA	LPPYQD	LIG_APCC_ABBA_1	0.1389
p.A87T	TCGA-FU-A3HZ	CESC	TCGA	LPPYQD	LIG_APCC_ABBA_1	0.0556
p.A102E	TCGA-YA-A8S7	LIHC	TCGA	LPPYQD	LIG_APCC_ABBA_1	0.7701
p.P98L	DO234250	ESAD	ICGC	LPPYQD	LIG_APCC_ABBA_1	0.6471
p.P98L	DO233767	GACA	ICGC	LPPYQD	LIG_APCC_ABBA_1	0.6471
p.N90T	DO234363	ESAD	ICGC	LPPYQD	LIG_APCC_ABBA_1	0.1389
p.G92C	DO22518	LGG	ICGC	LPPYQD	LIG_APCC_ABBA_1	0.1944
p.P111T	DO229018	LICA	ICGC	LPPYQD	LIG_APCC_ABBA_1	0.0833
p.D102N	DO219201	LUSC	ICGC	LPPYQD	LIG_APCC_ABBA_1	0.6932
p.A112T	SIDM00272	Breast Carcinoma	GDSC	LPPYQD	LIG_APCC_ABBA_1	0.0556
p.A112T	SIDM01617	Endometrial Carcinoma	GDSC	LPPYQD	LIG_APCC_ABBA_1	0.0556
p.G92D	ACH-002166	Skin Cancer	CCLE	LPPYQD	LIG_APCC_ABBA_1	0.1944
p.G92D	MZ7-mel	skin	COSMIC	LPPYQD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43699	Homeobox protein Nkx-2.1	LIG_APCC_ABBA_1	97:102	LPPYQD	APC,CDC20,FZR1	0.8332	More...
Q6ZTR5	Cilia- and flagella-associated protein 47	LIG_APCC_ABBA_1	1453:1458	LPPYQD	APC,CDC20,FZR1	0.6371	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons