DegronMD

Uniprot ID: Q6ZTR5

Source protein: Cilia- and flagella-associated protein 47

Source gene: CFAP47

Class: LIG_APCC_ABBA_1

Location: 1453:1458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6371

ASA_SCORE: 80.4667

COIL: 0.7048

CONS_SCORE: 0

DSS_SCORE: 0.6113

HELIX: 0.0808

FCONS_SCORE: 0

RIG_SCORE: 0.6996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1458E	SIDM00871	Non-Cancerous	GDSC	LPPYQD	LIG_APCC_ABBA_1	0.5647
p.D1458E	SIDM00872	Breast Carcinoma	GDSC	LPPYQD	LIG_APCC_ABBA_1	0.5647
p.D1458V	SIDM00528	Breast Carcinoma	GDSC	LPPYQD	LIG_APCC_ABBA_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43699	Homeobox protein Nkx-2.1	LIG_APCC_ABBA_1	97:102	LPPYQD	APC,CDC20,FZR1	0.8332	More...
Q6ZTR5	Cilia- and flagella-associated protein 47	LIG_APCC_ABBA_1	1453:1458	LPPYQD	APC,CDC20,FZR1	0.6371	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons