DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LPQTPPLE
Uniprot ID:
A2A3N6
Source protein:
Putative PIP5K1A and PSMD4-like protein
Source gene:
PIPSL
Class:
DEG_SCF_FBW7_2
Location:
460:467
E3 ligase:
FBXW7
DEGRON score:
0.9963
ASA_SCORE:
80.125
COIL:
0.8453
CONS_SCORE:
0.2305
DSS_SCORE:
0.6758
HELIX:
0.099
FCONS_SCORE:
1.0768
RIG_SCORE:
0.6791
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PIPSL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPQTPPLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q99755
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
DEG_SCF_FBW7_2
513:520
LPQTPPLE
FBXW7
0.9963
More...
A2A3N6
Putative PIP5K1A and PSMD4-like protein
DEG_SCF_FBW7_2
460:467
LPQTPPLE
FBXW7
0.9963
More...