DegronMD

Uniprot ID: Q99755

Source protein: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Source gene: PIP5K1A

Class: DEG_SCF_FBW7_2

Location: 513:520

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 71.8

COIL: 0.7858

CONS_SCORE: 0.2364

DSS_SCORE: 0.6941

HELIX: 0.1575

FCONS_SCORE: 1.0226

RIG_SCORE: 0.6751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G504V	TCGA-24-1469	OV	TCGA	LPQTPPLE	DEG_SCF_FBW7_2	0.0833
p.Q515E	TCGA-78-7539	LUAD	TCGA	LPQTPPLE	DEG_SCF_FBW7_2	0.5633
p.Q515H	TCGA-DK-A3X1	BLCA	TCGA	LPQTPPLE	DEG_SCF_FBW7_2	0.647
p.E524K	TCGA-ZF-AA51	BLCA	TCGA	LPQTPPLE	DEG_SCF_FBW7_2	0.2222
p.M503V	DO52752	CMDI	ICGC	LPQTPPLE	DEG_SCF_FBW7_2	0.0556
p.T505S	DO233764	GACA	ICGC	LPQTPPLE	DEG_SCF_FBW7_2	0.1111
p.H522Y	DO222908	MELA	ICGC	LPQTPPLE	DEG_SCF_FBW7_2	0.2778
p.H522R	DO38483	STAD	ICGC	LPQTPPLE	DEG_SCF_FBW7_2	0.2778
p.I528M	SIDM00319	Melanoma	GDSC	LPQTPPLE	DEG_SCF_FBW7_2	0.1111
p.I528M	VMRC-MELG	skin	COSMIC	LPQTPPLE	DEG_SCF_FBW7_2	0.1111
p.V505I	SIDM00220	Ovarian Carcinoma	GDSC	LPQTPPLE	DEG_SCF_FBW7_2	0.1111
p.L507R	SIDM01577	Plasma Cell Myeloma	GDSC	LPQTPPLE	DEG_SCF_FBW7_2	0.1667
p.P514L	SIDM01776	Plasma Cell Myeloma	GDSC	LPQTPPLE	DEG_SCF_FBW7_2	0.6471
p.L519S	ACH-000966	Ovarian Cancer	CCLE	LPQTPPLE	DEG_SCF_FBW7_2	0.6556
p.I516M	ACH-001704	Skin Cancer	CCLE	LPQTPPLE	DEG_SCF_FBW7_2	0.7618
p.I516M	VMRC-MELG	skin	COSMIC	LPQTPPLE	DEG_SCF_FBW7_2	0.7618
p.E511G	STS-0421	soft_tissue	COSMIC	LPQTPPLE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99755	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	DEG_SCF_FBW7_2	513:520	LPQTPPLE	FBXW7	0.9963	More...
A2A3N6	Putative PIP5K1A and PSMD4-like protein	DEG_SCF_FBW7_2	460:467	LPQTPPLE	FBXW7	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons