DegronMD

Uniprot ID: P0CJ85

Source protein: Double homeobox protein 4-like protein 2

Source gene: DUX4L2

Class: DEG_SCF_FBW7_1

Location: 3:9

E3 ligase: FBXW7

DEGRON score: 0.746

ASA_SCORE: 93.6571

COIL: 0.9264

CONS_SCORE: 0.3113

DSS_SCORE: 0.8298

HELIX: 0.0739

FCONS_SCORE: 1.0594

RIG_SCORE: 0.6621

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBX2	Double homeobox protein 4	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.5715	More...
P0CJ85	Double homeobox protein 4-like protein 2	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...
P0CJ86	Double homeobox protein 4-like protein 3	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...
P0CJ88	Double homeobox protein 4-like protein 5	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...
P0CJ89	Double homeobox protein 4-like protein 6	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...
P0CJ90	Double homeobox protein 4-like protein 7	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...
Q6RFH8	Double homeobox protein 4C	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.8858	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons