DegronMD

Uniprot ID: Q9UBX2

Source protein: Double homeobox protein 4

Source gene: DUX4

Class: DEG_SCF_FBW7_1

Location: 3:9

E3 ligase: FBXW7

DEGRON score: 0.5715

ASA_SCORE: 94.6143

COIL: 0.9254

CONS_SCORE: 0.3113

DSS_SCORE: 0.8298

HELIX: 0.0764

FCONS_SCORE: 1.0594

RIG_SCORE: 0.6621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C9R	DO51040	LAML	ICGC	LPTPSDS	DEG_SCF_FBW7_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6RFH8	Double homeobox protein 4C	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.8858	More...
Q9UBX2	Double homeobox protein 4	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.5715	More...
P0CJ85	Double homeobox protein 4-like protein 2	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...
P0CJ86	Double homeobox protein 4-like protein 3	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...
P0CJ88	Double homeobox protein 4-like protein 5	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...
P0CJ89	Double homeobox protein 4-like protein 6	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...
P0CJ90	Double homeobox protein 4-like protein 7	DEG_SCF_FBW7_1	3:9	LPTPSDS	FBXW7	0.746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons