DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 2240:2247

E3 ligase: FBXW7

DEGRON score: 0.5232

ASA_SCORE: 95.05

COIL: 0.9121

CONS_SCORE: 0.5236

DSS_SCORE: 0.589

HELIX: 0.0136

FCONS_SCORE: 1

RIG_SCORE: 0.6878

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2255I	TCGA-AN-A046	BRCA	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255I	DO1285	BRCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.V2232I	TCGA-AP-A1DK	UCEC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.V2232I	DO42033	UCEC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.S2235Y	TCGA-BS-A0UV	UCEC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.1944
p.S2235Y	DO42793	UCEC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1944
p.P2244H	TCGA-D1-A17Q	UCEC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.7694
p.P2244H	DO41903	UCEC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.7694
p.V2245I	TCGA-D8-A1XQ	BRCA	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.5965
p.V2245I	DO3095	BRCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.5965
p.P2244S	TCGA-EE-A3AF	SKCM	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.6752
p.P2244S	DO37911	SKCM	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.6752
p.A2257D	TCGA-VS-A9UA	CESC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.0556
p.A2257D	DO219730	CESC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.0556
p.T2247I	TCGA-XF-A8HD	BLCA	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.7078
p.T2247I	DO49795	BLCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.7078
p.A2257V	DO49675	LIAD	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.0556
p.A2257V	DO22802	LICA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.0556
p.T2255A	SIDM00435	Acute Myeloid Leukemia	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00434	Plasma Cell Myeloma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00373	Endometrial Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00611	Kidney Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01175	Other Sarcomas	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00993	Plasma Cell Myeloma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01036	Plasma Cell Myeloma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01005	Acute Myeloid Leukemia	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00569	Osteosarcoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00350	Head and Neck Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00955	Melanoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00391	Plasma Cell Myeloma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00259	Neuroblastoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00085	Glioma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00276	Biliary Tract Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00672	Hepatocellular Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00049	Colorectal Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00476	Ovarian Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00997	Thyroid Gland Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00794	Other Solid Cancers	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00574	Glioblastoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01191	Osteosarcoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01074	Glioblastoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM00273	Glioblastoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T2255A	SIDM01690	Plasma Cell Myeloma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.P2244L	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.7582
p.P2244L	ACH-000434	Lung Cancer	CCLE	LSATPVDT	DEG_SCF_FBW7_1	0.7582
p.P2244L	NCI-H1915	lung	COSMIC	LSATPVDT	DEG_SCF_FBW7_1	0.7582
p.A2237V	SIDM01254	Burkitt's Lymphoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSATPVDT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSATPVDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	944:951	LSATPVDT	FBXW7	0.7889	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1416:1423	LSATPVDT	FBXW7	0.5732	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2240:2247	LSATPVDT	FBXW7	0.5232	More...