DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 944:951

E3 ligase: FBXW7

DEGRON score: 0.7889

ASA_SCORE: 94.8

COIL: 0.9071

CONS_SCORE: 0.5236

DSS_SCORE: 0.6431

HELIX: 0.0136

FCONS_SCORE: 1

RIG_SCORE: 0.6752

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A961V	TCGA-09-2051	OV	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.0556
p.A961V	DO31450	OV	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.0556
p.R942T	TCGA-49-4494	LUAD	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.2778
p.R942T	TCGA-NK-A7XE	LUSC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.2778
p.R942T	DO24245	LUAD	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.2778
p.R942T	DO219215	LUSC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.2778
p.P935S	TCGA-55-8089	LUAD	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935S	TCGA-D9-A6EC	SKCM	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935S	DO23690	LUAD	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935S	DO50291	SKCM	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.T951N	TCGA-70-6722	LUSC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.7055
p.T951N	DO27755	LUSC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.7055
p.T951N	SIDM00232	Kidney Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.7055
p.T951N	ACH-002168	Kidney Cancer	CCLE	LSATPVDT	DEG_SCF_FBW7_1	0.7055
p.T951N	NCC021	kidney	COSMIC	LSATPVDT	DEG_SCF_FBW7_1	0.7055
p.A961T	TCGA-A5-A0G2	UCEC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.0556
p.A961T	DO41235	UCEC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.0556
p.V936I	TCGA-AP-A0LM	UCEC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.V936I	DO43306	UCEC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.P935T	TCGA-AX-A2HC	UCEC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935T	TCGA-CV-7245	HNSC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935T	DO14322	HNSC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935T	DO41572	UCEC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.E940Q	TCGA-C8-A12T	BRCA	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.2222
p.E940Q	DO5507	BRCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.2222
p.T947S	TCGA-CV-7178	HNSC	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.7116
p.T947S	TCGA-RB-AA9M	PAAD	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.7116
p.T947S	DO14774	HNSC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.7116
p.T947S	DO51718	PAAD	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.7116
p.V937L	TCGA-L5-A4OJ	ESCA	TCGA	LSATPVDT	DEG_SCF_FBW7_1	0.1389
p.E940V	DO227976	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.2222
p.T959A	DO222755	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T959A	DO222869	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T959A	DO229013	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T959A	DO229016	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T959A	DO52365	LUSC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.T959A	DO52357	LUSC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.1111
p.A941V	DO222849	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.25
p.A941V	DO229013	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.25
p.A941V	DO229016	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.25
p.R942S	DO229013	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.2778
p.R942S	DO229016	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.2778
p.R942S	DO52365	LUSC	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.2778
p.E940G	DO229013	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.2222
p.E940G	DO229016	COCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.2222
p.A946T	DO228943	LICA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.6028
p.A946T	DO229004	LICA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.6028
p.V949I	DO229462	SKCA	ICGC	LSATPVDT	DEG_SCF_FBW7_1	0.5965
p.P935L	SIDM00454	Rhabdomyosarcoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935L	SIDM00928	Breast Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935L	SIDM00814	Other Solid Cancers	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935L	SIDM00943	Pancreatic Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935L	SIDM00808	Burkitt's Lymphoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.P935L	SIDM01254	Burkitt's Lymphoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.0833
p.D950N	SIDM00477	Esophageal Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.5821
p.D950N	ACH-000383	Esophageal Cancer	CCLE	LSATPVDT	DEG_SCF_FBW7_1	0.5821
p.D950N	OE33	oesophagus	COSMIC	LSATPVDT	DEG_SCF_FBW7_1	0.5821
p.V937I	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.1389
p.V937I	ACH-000853	Lung Cancer	CCLE	LSATPVDT	DEG_SCF_FBW7_1	0.1389
p.V937I	NCI-H661	lung	COSMIC	LSATPVDT	DEG_SCF_FBW7_1	0.1389
p.A941D	SIDM00148	Breast Carcinoma	GDSC	LSATPVDT	DEG_SCF_FBW7_1	0.25
p.A941D	MCF7	breast	COSMIC	LSATPVDT	DEG_SCF_FBW7_1	0.25
p.T943K	ACH-001321	Thyroid Cancer	CCLE	LSATPVDT	DEG_SCF_FBW7_1	0.75
p.T943K	TT	thyroid	COSMIC	LSATPVDT	DEG_SCF_FBW7_1	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSATPVDT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSATPVDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	944:951	LSATPVDT	FBXW7	0.7889	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1416:1423	LSATPVDT	FBXW7	0.5732	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2240:2247	LSATPVDT	FBXW7	0.5232	More...