DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 2358:2365

E3 ligase: FBXW7

DEGRON score: 0.777

ASA_SCORE: 92.4375

COIL: 0.9161

CONS_SCORE: 0.5236

DSS_SCORE: 0.5491

HELIX: 0.012

FCONS_SCORE: 0.8936

RIG_SCORE: 0.6819

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2360K	TCGA-BP-4983	KIRC	TCGA	LSTTPADT	DEG_SCF_FBW7_1	0.6195
p.T2360K	DO16705	KIRC	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.6195
p.M2349T	TCGA-DD-AACF	LIHC	TCGA	LSTTPADT	DEG_SCF_FBW7_1	0.0833
p.M2349T	DO52201	LIHC	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.0833
p.Q2374E	DO1156	BRCA	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.0833
p.T2367I	DO229062	LICA	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.2778
p.S2352C	DO48715	LIRI	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.1667
p.T2355K	DO230968	LUSC	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355K	DO224621	LUSC	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM01652	Non-Cancerous	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM00266	Ewing's Sarcoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM01161	Other Sarcomas	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM00899	Pancreatic Carcinoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM00223	Small Cell Lung Carcinoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM00853	Other Sarcomas	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM00836	Colorectal Carcinoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM00063	Melanoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM01107	Melanoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM01193	Glioma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM01757	Bladder Carcinoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.T2355I	SIDM01566	Hodgkin's Lymphoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.25
p.L2358I	SIDM00594	Acute Myeloid Leukemia	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.6063
p.L2358I	SIDM00263	Ewing's Sarcoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.6063
p.L2358I	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.6063
p.V2350G	SIDM00500	Colorectal Carcinoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.1111
p.V2350G	ACH-000959	Colon/Colorectal Cancer	CCLE	LSTTPADT	DEG_SCF_FBW7_1	0.1111
p.T2365S	SIDM01215	Ovarian Carcinoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.6005
p.T2365S	ACH-000542	Ovarian Cancer	CCLE	LSTTPADT	DEG_SCF_FBW7_1	0.6005

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTTPADT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSTTPADT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2358:2365	LSTTPADT	FBXW7	0.777	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3301:3308	LSTTPADT	FBXW7	0.9637	More...