DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 3301:3308

E3 ligase: FBXW7

DEGRON score: 0.9637

ASA_SCORE: 90.725

COIL: 0.9166

CONS_SCORE: 0.5236

DSS_SCORE: 0.5996

HELIX: 0.0133

FCONS_SCORE: 1

RIG_SCORE: 0.6671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V3293L	TCGA-AR-A1AO	BRCA	TCGA	LSTTPADT	DEG_SCF_FBW7_1	0.1111
p.V3293L	DO4443	BRCA	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.1111
p.T3292M	TCGA-BR-8591	STAD	TCGA	LSTTPADT	DEG_SCF_FBW7_1	0.0833
p.T3292M	DO47973	STAD	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.0833
p.T3292M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.0833
p.T3292M	ACH-000922	Leukemia	CCLE	LSTTPADT	DEG_SCF_FBW7_1	0.0833
p.T3292M	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPADT	DEG_SCF_FBW7_1	0.0833
p.T3313N	TCGA-D7-5579	STAD	TCGA	LSTTPADT	DEG_SCF_FBW7_1	0.1944
p.T3313N	DO38571	STAD	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.1944
p.S3299G	TCGA-E7-A4IJ	BLCA	TCGA	LSTTPADT	DEG_SCF_FBW7_1	0.2778
p.S3299G	DO453	BLCA	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.2778
p.D3307N	TCGA-HU-A4G8	STAD	TCGA	LSTTPADT	DEG_SCF_FBW7_1	0.5821
p.D3307N	DO47819	STAD	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.5821
p.S3299N	DO224754	COCA	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.2778
p.S3299N	DO229013	COCA	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.2778
p.S3299N	DO229016	COCA	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.2778
p.S3299N	DO52365	LUSC	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.2778
p.T3300S	DO224754	COCA	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.3056
p.A3318G	DO231075	LUSC	ICGC	LSTTPADT	DEG_SCF_FBW7_1	0.0556
p.V3312G	SIDM00120	Prostate Carcinoma	GDSC	LSTTPADT	DEG_SCF_FBW7_1	0.2222
p.V3312G	ACH-000979	Prostate Cancer	CCLE	LSTTPADT	DEG_SCF_FBW7_1	0.2222
p.V3312G	DU-145	prostate	COSMIC	LSTTPADT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons