DegronMD

Uniprot ID: P10914

Source protein: Interferon regulatory factor 1

Source gene: IRF1

Class: DEG_SCF_FBW7_1

Location: 179:184

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 70.6

COIL: 0.8817

CONS_SCORE: 0.3501

DSS_SCORE: 0.3612

HELIX: 0.0675

FCONS_SCORE: 0.8577

RIG_SCORE: 0.7759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D194V	TCGA-BR-7704	STAD	TCGA	LTPALS	DEG_SCF_FBW7_1	0.0556
p.D194V	DO38360	STAD	ICGC	LTPALS	DEG_SCF_FBW7_1	0.0556
p.S184L	TCGA-FI-A2D5	UCEC	TCGA	LTPALS	DEG_SCF_FBW7_1	0.8778
p.S184L	DO41331	UCEC	ICGC	LTPALS	DEG_SCF_FBW7_1	0.8778
p.QD171QN	DO220906	MELA	ICGC	LTPALS	DEG_SCF_FBW7_1	0
p.D172N	DO220906	MELA	ICGC	LTPALS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10914	Interferon regulatory factor 1	DEG_SCF_FBW7_1	179:184	LTPALS	FBXW7	0.9979	More...
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	7522:7527	LTPALS	FBXW7	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons