DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 7522:7527

E3 ligase: FBXW7

DEGRON score: 0.9883

ASA_SCORE: 85.55

COIL: 0.8365

CONS_SCORE: 0

DSS_SCORE: 0.5209

HELIX: 0.0232

FCONS_SCORE: 0

RIG_SCORE: 0.7401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S7527C	TCGA-34-8454	LUSC	TCGA	LTPALS	DEG_SCF_FBW7_1	0.8652
p.S7527C	DO50094	LUSC	ICGC	LTPALS	DEG_SCF_FBW7_1	0.8652
p.T7529S	TCGA-B6-A0RE	BRCA	TCGA	LTPALS	DEG_SCF_FBW7_1	0.2778
p.T7529S	DO3482	BRCA	ICGC	LTPALS	DEG_SCF_FBW7_1	0.2778
p.G7515V	TCGA-FS-A1ZP	SKCM	TCGA	LTPALS	DEG_SCF_FBW7_1	0.1389
p.G7515V	DO37703	SKCM	ICGC	LTPALS	DEG_SCF_FBW7_1	0.1389
p.S7527Y	TCGA-G2-A2ES	BLCA	TCGA	LTPALS	DEG_SCF_FBW7_1	0.8231
p.S7527Y	DO785	BLCA	ICGC	LTPALS	DEG_SCF_FBW7_1	0.8231
p.T7523A	TCGA-GN-A4U5	SKCM	TCGA	LTPALS	DEG_SCF_FBW7_1	0.825
p.T7523A	DO51257	SKCM	ICGC	LTPALS	DEG_SCF_FBW7_1	0.825
p.P7524T	TCGA-LN-A7HW	ESCA	TCGA	LTPALS	DEG_SCF_FBW7_1	0.7031
p.D7516N	TCGA-MP-A4TC	LUAD	TCGA	LTPALS	DEG_SCF_FBW7_1	0.1667
p.D7516N	DO45342	LUAD	ICGC	LTPALS	DEG_SCF_FBW7_1	0.1667
p.P7536Q	TCGA-VS-A8EI	CESC	TCGA	LTPALS	DEG_SCF_FBW7_1	0.0833
p.P7536Q	DO51621	CESC	ICGC	LTPALS	DEG_SCF_FBW7_1	0.0833
p.M7514I	SIDM00291	Melanoma	GDSC	LTPALS	DEG_SCF_FBW7_1	0.1111
p.M7514I	ACH-002040	Skin Cancer	CCLE	LTPALS	DEG_SCF_FBW7_1	0.1111
p.M7514I	HMV-II	skin	COSMIC	LTPALS	DEG_SCF_FBW7_1	0.1111
p.M7514L	SIDM00890	Melanoma	GDSC	LTPALS	DEG_SCF_FBW7_1	0.1111
p.M7514L	ACH-000580	Skin Cancer	CCLE	LTPALS	DEG_SCF_FBW7_1	0.1111
p.M7514L	C32	skin	COSMIC	LTPALS	DEG_SCF_FBW7_1	0.1111
p.S7512C	SIDM00937	Oral Cavity Carcinoma	GDSC	LTPALS	DEG_SCF_FBW7_1	0.0556
p.S7512C	CAL-27	upper_aerodigestive_tract	COSMIC	LTPALS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10914	Interferon regulatory factor 1	DEG_SCF_FBW7_1	179:184	LTPALS	FBXW7	0.9979	More...
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	7522:7527	LTPALS	FBXW7	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons