DegronMD

Uniprot ID: O75154

Source protein: Rab11 family-interacting protein 3

Source gene: RAB11FIP3

Class: DEG_SCF_FBW7_1

Location: 419:424

E3 ligase: FBXW7

DEGRON score: 0.9784

ASA_SCORE: 74.3

COIL: 0.8683

CONS_SCORE: 0.5286

DSS_SCORE: 0.4802

HELIX: 0.1007

FCONS_SCORE: 0.9912

RIG_SCORE: 0.7095

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G412C	TCGA-55-A490	LUAD	TCGA	LTPSPT	DEG_SCF_FBW7_1	0.1389
p.G412C	DO24596	LUAD	ICGC	LTPSPT	DEG_SCF_FBW7_1	0.1389
p.R426Q	TCGA-D6-6515	HNSC	TCGA	LTPSPT	DEG_SCF_FBW7_1	0.2778
p.K425N	TCGA-DX-A6YT	SARC	TCGA	LTPSPT	DEG_SCF_FBW7_1	0.3056
p.R426W	TCGA-EO-A3B0	UCEC	TCGA	LTPSPT	DEG_SCF_FBW7_1	0.2778
p.V419I	DO227906	COCA	ICGC	LTPSPT	DEG_SCF_FBW7_1	0.7076
p.A427V	DO234219	ESAD	ICGC	LTPSPT	DEG_SCF_FBW7_1	0.25
p.D424V	DO52163	LIHC	ICGC	LTPSPT	DEG_SCF_FBW7_1	0.7785
p.S422I	DO50679	ORCA	ICGC	LTPSPT	DEG_SCF_FBW7_1	0.623
p.A417T	SIDM01090	Colorectal Carcinoma	GDSC	LTPSPT	DEG_SCF_FBW7_1	0.2778
p.A417T	ACH-000943	Colon/Colorectal Cancer	CCLE	LTPSPT	DEG_SCF_FBW7_1	0.2778
p.A417T	RKO	large_intestine	COSMIC	LTPSPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75154	Rab11 family-interacting protein 3	DEG_SCF_FBW7_1	419:424	LTPSPT	FBXW7	0.9784	More...
Q5TG53	Putative uncharacterized protein SERTAD4-AS1	DEG_SCF_FBW7_1	148:153	LTPSPT	FBXW7	0.9566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons