DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LTPSPT
Uniprot ID:
Q5TG53
Source protein:
Putative uncharacterized protein SERTAD4-AS1
Source gene:
SERTAD4-AS1
Class:
DEG_SCF_FBW7_1
Location:
148:153
E3 ligase:
FBXW7
DEGRON score:
0.9566
ASA_SCORE:
69.4167
COIL:
0.8763
CONS_SCORE:
0
DSS_SCORE:
0.723
HELIX:
0.0235
FCONS_SCORE:
0
RIG_SCORE:
0.6735
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SERTAD4-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPSPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75154
Rab11 family-interacting protein 3
DEG_SCF_FBW7_1
419:424
LTPSPT
FBXW7
0.9784
More...
Q5TG53
Putative uncharacterized protein SERTAD4-AS1
DEG_SCF_FBW7_1
148:153
LTPSPT
FBXW7
0.9566
More...