DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
MRPRLWLLL
Uniprot ID:
A6NJW9
Source protein:
T-cell surface glycoprotein CD8 beta-2 chain
Source gene:
CD8B2
Class:
DEG_APCC_DBOX_1
Location:
1:9
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8025
ASA_SCORE:
70.7778
COIL:
0.3319
CONS_SCORE:
0.769
DSS_SCORE:
0.268
HELIX:
0.617
FCONS_SCORE:
1.2882
RIG_SCORE:
0.9093
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CD8B2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MRPRLWLLL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P10966
T-cell surface glycoprotein CD8 beta chain
DEG_APCC_DBOX_1
1:9
MRPRLWLLL
APC,CDC20,FZR1
0.882
More...
A6NJW9
T-cell surface glycoprotein CD8 beta-2 chain
DEG_APCC_DBOX_1
1:9
MRPRLWLLL
APC,CDC20,FZR1
0.8025
More...