DegronMD

Uniprot ID: P10966

Source protein: T-cell surface glycoprotein CD8 beta chain

Source gene: CD8B

Class: DEG_APCC_DBOX_1

Location: 1:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.882

ASA_SCORE: 72.2333

COIL: 0.3481

CONS_SCORE: 0.7682

DSS_SCORE: 0.268

HELIX: 0.484

FCONS_SCORE: 1.2887

RIG_SCORE: 0.9093

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N19S	TCGA-49-AARE	LUAD	TCGA	MRPRLWLLL	DEG_APCC_DBOX_1	0.0556
p.N19S	DO218922	LUAD	ICGC	MRPRLWLLL	DEG_APCC_DBOX_1	0.0556
p.L16I	TCGA-B5-A3FC	UCEC	TCGA	MRPRLWLLL	DEG_APCC_DBOX_1	0.1389
p.L16I	DO41871	UCEC	ICGC	MRPRLWLLL	DEG_APCC_DBOX_1	0.1389
p.L16F	TCGA-BF-A5EO	SKCM	TCGA	MRPRLWLLL	DEG_APCC_DBOX_1	0.1389
p.L16F	DO219450	SKCM	ICGC	MRPRLWLLL	DEG_APCC_DBOX_1	0.1389
p.R2W	DO232761	PBCA	ICGC	MRPRLWLLL	DEG_APCC_DBOX_1	0.8634
p.H17Q	SIDM00286	Neuroblastoma	GDSC	MRPRLWLLL	DEG_APCC_DBOX_1	0.1111
p.H17Q	SIDM01134	Small Cell Lung Carcinoma	GDSC	MRPRLWLLL	DEG_APCC_DBOX_1	0.1111
p.H17Q	SIDM00833	Colorectal Carcinoma	GDSC	MRPRLWLLL	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10966	T-cell surface glycoprotein CD8 beta chain	DEG_APCC_DBOX_1	1:9	MRPRLWLLL	APC,CDC20,FZR1	0.882	More...
A6NJW9	T-cell surface glycoprotein CD8 beta-2 chain	DEG_APCC_DBOX_1	1:9	MRPRLWLLL	APC,CDC20,FZR1	0.8025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons