DegronMD

Uniprot ID: O95153

Source protein: Peripheral-type benzodiazepine receptor-associated protein 1

Source gene: TSPOAP1

Class: LIG_APCC_ABBA_1

Location: 1060:1065

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9917

ASA_SCORE: 67.7167

COIL: 0.824

CONS_SCORE: 0.5452

DSS_SCORE: 0.424

HELIX: 0.0198

FCONS_SCORE: 1.064

RIG_SCORE: 0.6578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1055L	SIDM01617	Endometrial Carcinoma	GDSC	MSPHGE	LIG_APCC_ABBA_1	0.1944
p.P1071T	U-87-MG	central_nervous_system	COSMIC	MSPHGE	LIG_APCC_ABBA_1	0.1667
p.P1059T	SNU-C5	large_intestine	COSMIC	MSPHGE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95153	Peripheral-type benzodiazepine receptor-associated protein 1	LIG_APCC_ABBA_1	1060:1065	MSPHGE	APC,CDC20,FZR1	0.9917	More...
Q02108	Guanylate cyclase soluble subunit alpha-1	LIG_APCC_ABBA_1	564:569	MSPHGE	APC,CDC20,FZR1	0.8233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons