DegronMD

Uniprot ID: Q02108

Source protein: Guanylate cyclase soluble subunit alpha-1

Source gene: GUCY1A1

Class: LIG_APCC_ABBA_1

Location: 564:569

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8233

ASA_SCORE: 76.8167

COIL: 0.8497

CONS_SCORE: 0.4339

DSS_SCORE: 0.3473

HELIX: 0.0065

FCONS_SCORE: 0.7054

RIG_SCORE: 0.7034

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L559F	SIDM00789	Colorectal Carcinoma	GDSC	MSPHGE	LIG_APCC_ABBA_1	0.1944
p.L559F	HCT-15	large_intestine	COSMIC	MSPHGE	LIG_APCC_ABBA_1	0.1944
p.P566L	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	MSPHGE	LIG_APCC_ABBA_1	0.6471
p.P566L	KYSE-270	oesophagus	COSMIC	MSPHGE	LIG_APCC_ABBA_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95153	Peripheral-type benzodiazepine receptor-associated protein 1	LIG_APCC_ABBA_1	1060:1065	MSPHGE	APC,CDC20,FZR1	0.9917	More...
Q02108	Guanylate cyclase soluble subunit alpha-1	LIG_APCC_ABBA_1	564:569	MSPHGE	APC,CDC20,FZR1	0.8233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons